Evidence map›Paper›PMID 26466939›Full record

ArticleJournal of assisted reproduction and genetics2015

Acute immunomodulatory changes during controlled ovarian stimulation: evidence from the first trial investigating the short-term effects of estradiol on biomarkers and B cells involved in autoimmunity.

Anna Ghirardello, Salvatore Gizzo, Marco Noventa, Michela Quaranta, Amerigo Vitagliano, Nicoletta Gallo, Giorgia Pantano, Marianna Beggio, Chiara Cosma, Michele Gangemi and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Anna GhirardelloDivision of Rheumatology, Department of Medicine, University of Padua, Padua, Italy.
Salvatore GizzoDepartment of Woman and Child Health, Gynaecologic and Obstetric Unit, University of Padua, Padua, Italy. ginecologia_padova@libero.it.
Marco NoventaDepartment of Woman and Child Health, Gynaecologic and Obstetric Unit, University of Padua, Padua, Italy.
Michela QuarantaDepartment of Obstetrics and Gynaecology, University of Verona, Verona, Italy.
Amerigo VitaglianoDepartment of Woman and Child Health, Gynaecologic and Obstetric Unit, University of Padua, Padua, Italy.
Nicoletta GalloDepartment of Laboratory Medicine, University of Padua, Padua, Italy.
Giorgia PantanoDepartment of Laboratory Medicine, University of Padua, Padua, Italy.
Marianna BeggioDivision of Rheumatology, Department of Medicine, University of Padua, Padua, Italy.
Chiara CosmaDepartment of Laboratory Medicine, University of Padua, Padua, Italy.
Michele GangemiDepartment of Woman and Child Health, Gynaecologic and Obstetric Unit, University of Padua, Padua, Italy.
Mario PlebaniDepartment of Laboratory Medicine, University of Padua, Padua, Italy.
Andrea DoriaDivision of Rheumatology, Department of Medicine, University of Padua, Padua, Italy.
University of Padua · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the present study was to evaluate the in vivo immunomodulatory effects of an acute short-term estradiol (E(2)) increase on serum levels of B cell-activating factor (BAFF), immunoglobulins (Ig), anti-nuclear antibodies (ANA), and the peripheral B cell phenotype.

methodsWe conducted, at the Infertility Center of the University of Padua, a prospective case-control study on a cohort of infertile normo-responder women (group-A, 63 patients) undergoing controlled ovarian stimulation (COS) compared with an age-matched cohort of normo-ovulatory healthy women (group-B, 39 patients). Three serial blood sample assays were conducted in both groups, at T0, hypothalamic suppression; T1, ovulation induction; and T2, βhCG test in group A, and at T0, 2nd day; T1, 14th day; and T2, 21st day of cycle in group B, and serum levels of E(2) and BAFF, BAFF/E(2) ratio, circulating IgM, IgG, and IgA, ANA titer, and peripheral B cell phenotype were measured. We compared group-A versus group-B in terms of absolute and E(2) normalized values of BAFF at baseline (T0) to verify for possible differences between healthy and infertile women, at T1 to verify for possible differences occurring after spontaneous ovulation versus COS, and at T2 to evaluate differences in serum BAFF levels between pregnant versus non-pregnant patients (considering only group-A) and between non-pregnant women after spontaneous versus COS cycles (group-B versus group-A). In group-A, we also evaluated IgM, IgG, IgA levels, ANA titer, and peripheral B cell phenotype at T0 versus T1 versus T2.

resultsWith the exception of E(2) levels at T1 (as expected), no significant differences were found between the two groups for all outcome measures. In group-A, BAFF at T0 positively correlated with IgM levels; marginal zone CD19+/CD27+/IgD+ memory B cell compartment tended to be expanded at T1 when compared with T0.

conclusionsDespite several mechanistic and clinical studies supporting a stimulatory role of E(2) on autoimmunity, the acute increase of E(2) during COS for infertility treatment does not seem to have a major impact on the immune system.

Indexed as

AdultAntibodies, AntinuclearAutoimmunityB-Cell Activating FactorBiomarkersB-LymphocytesCase-Control StudiesEstradiolFemaleHumansImmunoglobulinsImmunomodulationOvulation InductionAntibodies, AntinuclearB-Cell Activating FactorBiomarkersEstradiolImmunoglobulinsAcute immunomodulationAutoimmunity biomarkersBAFFBLySControlled ovarian stimulationIVFMemory B cellsShort-term estradiol increase

Identifiers

PMID26466939
PMCPMC4681742
OpenAlexW1939464039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.