Evidence map›Paper›PMID 26466860›Full record

ArticleThe Annals of otology, rhinology, and laryngology2016

Predictors of Posterior Glottic Stenosis: A Multi-Institutional Case-Control Study.

Alexander T Hillel, Selmin Karatayli-Ozgursoy, Idris Samad, Simon R A Best, Vinciya Pandian, Laureano Giraldez, Jennifer Gross, Christopher Wootten, Alexander Gelbard, Lee M Akst and 2 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in The Annals of otology, rhinology, and laryngology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03250975 (Incidence of Acute Laryngeal Injury Following Endotracheal Intubation), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03250975 phase1 / phase2active not recruitingnot on this mapstarted 2017, after this paper: background citation

Incidence of Acute Laryngeal Injury Following Endotracheal Intubation

TypeinterventionalSponsorVanderbilt University Medical CenterRan2017 to 2026Enrolled64ConditionsIntubation ComplicationArmsBudesonide and Azithromycin, Placebo control of budesonide and azithromycin
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
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  8. Review
  9. The ESTS-AIR database-initial results of a multi-institutional database on airway surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024
    Article
  10. Article
  11. Article
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  13. Clinical Predictors of Postintubation Bilateral Vocal Fold Immobility.International archives of otorhinolaryngology · 2022
    Article
  14. Review
  15. Article
  16. Identifying Phenotypically Distinct Fibroblast Subsets in Type 2 Diabetes-Associated Iatrogenic Laryngotracheal Stenosis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2022
    Article
  17. Article
  18. Factors Affecting Dilation Interval in Patients With Granulomatosis With Polyangiitis-Associated Subglottic and Glottic Stenosis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2021
    Article
  19. Article
  20. Multidisciplinary Safety Recommendations After Tracheostomy During COVID-19 Pandemic: State of the Art Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Alexander T HillelJohns Hopkins University School of Medicine, Otolaryngology, Head & Neck Surgery, Baltimore, Maryland, USA ahillel@jhmi.edu.
Selmin Karatayli-OzgursoyJohns Hopkins University School of Medicine, Otolaryngology, Head & Neck Surgery, Baltimore, Maryland, USA.
Idris SamadJohns Hopkins University School of Medicine, Otolaryngology, Head & Neck Surgery, Baltimore, Maryland, USA.
Simon R A BestJohns Hopkins University School of Medicine, Otolaryngology, Head & Neck Surgery, Baltimore, Maryland, USA.
Vinciya PandianJohns Hopkins University School of Medicine, Otolaryngology, Head & Neck Surgery, Baltimore, Maryland, USA.
Laureano GiraldezEmory University School of Medicine, Department of Otolaryngology, Head & Neck Surgery, Atlanta, Georgia, USA.
Jennifer GrossEmory University School of Medicine, Department of Otolaryngology, Head & Neck Surgery, Atlanta, Georgia, USA.
Christopher WoottenVanderbilt University Medical Center, Department of Otolaryngology, Head & Neck Surgery, Nashville, Tennessee, USA.
Alexander GelbardVanderbilt University Medical Center, Department of Otolaryngology, Head & Neck Surgery, Nashville, Tennessee, USA.
Lee M AkstJohns Hopkins University School of Medicine, Otolaryngology, Head & Neck Surgery, Baltimore, Maryland, USA.
Michael M JohnsEmory University School of Medicine, Department of Otolaryngology, Head & Neck Surgery, Atlanta, Georgia, USA.
North American Airway Collaborative (NoAAC)
Johns Hopkins Medicine · USEmory University · USJohns Hopkins University · USVanderbilt University Medical Center · US

Funding

Immune Cell Modulation in Laryngotrachael FibrosisK23DC014082 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLEL, ALEXANDER · 2015 to 2019
$1.2M
NIDCD NIH HHS K23 DC014082
6 · The paper itself

Abstract

objectiveTo assess intrinsic and extrinsic risk factors in the development of posterior glottic stenosis (PGS) in intubated patients.

methodsPatients diagnosed with PGS between September 2012 and May 2014 at 3 tertiary care university hospitals were included. Patient demographics, comorbidities, duration of intubation, endotracheal tube (ETT) size, and indication for intubation were recorded. Patients with PGS were compared to control patients represented by patients intubated in intensive care units (ICU).

resultsThirty-six PGS patients were identified. After exclusion, 28 PGS patients (14 male, 14 female) and 112 (65 male, 47 female) controls were studied. Multivariate analysis demonstrated ischemia (P < .05), diabetes (P < .01), and length of intubation (P < .01) were significant risk factors for the development of PGS. Fourteen of 14 (100%) males were intubated with a size 8 or larger ETT compared to 47 of 65 (72.3%) male controls (P < .05). Posterior glottic stenosis (P < .01), length of intubation (P < .001), and obstructive sleep apnea (P < .05) were significant risk factors for tracheostomy.

conclusionDuration of intubation, ischemia, diabetes mellitus, and large ETT size (8 or greater) in males were significant risk factors for the development of PGS. Reducing the use of size 8 ETTs and earlier planned tracheostomy in high-risk patients may reduce the incidence of PGS and improve ICU safety.

Indexed as

AdultAgedCase-Control StudiesDiabetes ComplicationsFemaleHumansHypertensionIntubation, IntratrachealIschemiaLaryngostenosisMaleMiddle AgedRisk FactorsSleep Apnea, ObstructiveTime FactorsTracheostomyfibrosishospital safetyintubationlaryngotracheal stenosistracheostomy

Identifiers

PMID26466860
PMCPMC4742396
OpenAlexW2262838662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.