ArticleCardiovascular diabetology2015
Association of serum omentin levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: a hospital-based study.
Article in Cardiovascular diabetology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Severity of Cardiovascular Autonomic Neuropathy Is Linked to Increasing Levels of Circulating Proinflammatory Cytokines.Diabetes, obesity & metabolism · 2026Observational
- Association of baseline and trajectory of triglyceride-glucose index with the incidence of cardiovascular autonomic neuropathy in type 2 diabetes mellitus.Cardiovascular diabetology · 2025Article
- Remodeling of the Intracardiac Ganglia During the Development of Cardiovascular Autonomic Dysfunction in Type 2 Diabetes: Molecular Mechanisms and Therapeutics.International journal of molecular sciences · 2024Review
- Association of serum omentin levels with microvascular complications of type 2 diabetes mellitus: a systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2024Review
- Article
- Association of serum CTRP9 levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus.Journal of diabetes investigation · 2021Article
- Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin.Journal of family medicine and primary care · 2020Article
- Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes.Diabetologia · 2020Article
- Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population.Mediators of inflammation · 2020Article
- Newly Discovered Adipokines: Pathophysiological Link Between Obesity and Cardiometabolic Disorders.Frontiers in physiology · 2020Review
- Association between Omentin-1 and Coronary Artery Disease: Pathogenesis and Clinical Research.Current cardiology reviews · 2020Review
- The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus.BioMed research international · 2019Article
- The association between omentin and diabetes: a systematic review and meta-analysis of observational studies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Peripheral Sensory Neuropathy and associated factors among adult diabetes mellitus patients in Bahr Dar, Ethiopia.Journal of diabetes and metabolic disorders · 2017Article
- Association between omentin-1 expression in human epicardial adipose tissue and coronary atherosclerosis.Cardiovascular diabetology · 2016Article
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6 authors.
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Abstract
backgroundWhereas a few studies have reported associations of serum omentin levels with subclinical atherosclerosis in patients with diabetes, little information is available with respect to the associations of serum omentin levels and diabetic microvascular complications. The aim of this study was to investigate the relationships of serum omentin levels and vascular complications including cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM).
methodsWe recruited 97 patients who evaluated complications of diabetes. CAN was assessed by five standard cardiovascular reflex tests according to Ewing's protocol. Diabetic nephropathy (DN), retinopathy (DR), and peripheral neuropathy (DPN) were evaluated. Serum omentin levels were assessed by ELISA. Atherosclerotic burden was evaluated by measuring the brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI).
resultsThe prevalence of CAN increased borderline significantly across the omentin tertiles (p = 0.05) and CAN point increased significantly and progressively across the omentin tertiles (p = 0.013). The prevalence of other microvascular complications (DPN, DN, and DR) did not differ among omentin tertiles. The mean levels of baPWV also increased significantly and progressively across the omentin tertiles (p = 0.002). Serum omentin levels were significantly positively correlated with CAN point (p = 0.004) and borderline significantly correlated with baPWV (p = 0.05) after multivariate adjustment. Regarding linear regression analysis for CAN point, univariate regression analysis demonstrated that CAN point associated with omentin, diastolic blood pressure (DBP) and hsCRP. Multiple regression analysis revealed that omentin levels, together DBP and baPWV correlated with CAN point. This present study suggests that serum omentin levels may be independently associate with CAN in patients with T2DM.
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