Evidence map›Paper›PMID 26466541›Full record

ReviewInsects2012

New Insights into Control of Arbovirus Replication and Spread by Insect RNA Interference Pathways.

Claire L Donald, Alain Kohl, Esther Schnettler

Open access · goldAbstract readReview
In one paragraph

Review in Insects, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Transovarial transmission of mosquito-borne viruses: a systematic review.Frontiers in cellular and infection microbiology · 2023
    Pooled it
  2. Potential effect ofFrontiers in microbiology · 2025
    Article
  3. Dicer-2 mutations inThe Journal of general virology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Symbiotic Interactions Between Mosquitoes and Mosquito Viruses.Frontiers in cellular and infection microbiology · 2021
    Review
  9. Vector Specificity of Arbovirus Transmission.Frontiers in microbiology · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Claire L DonaldMRC-University of Glasgow Centre for Virus Research, 8 Church Street, Glasgow G11 5JR, Scotland, UK. c.donald.1@research.gla.ac.uk.
Alain KohlMRC-University of Glasgow Centre for Virus Research, 8 Church Street, Glasgow G11 5JR, Scotland, UK. alain.kohl@glasgow.ac.uk.
Esther SchnettlerMRC-University of Glasgow Centre for Virus Research, 8 Church Street, Glasgow G11 5JR, Scotland, UK. Esther.Schnettler@glasgow.ac.uk.
University of Glasgow · GBMRC University of Glasgow Centre for Virus Research · GB

Funding

Medical Research Council MC_UP_A550_1031Medical Research Council MC_UU_12014/8
6 · The paper itself

Abstract

Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control these pathogens. Small RNA-mediated host responses are key players among these antiviral immune strategies. Studies into one such small RNA-mediated antiviral response, the exogenous RNA interference (RNAi) pathway, have generated a wealth of information on the functions of this mechanism and the enzymes which mediate antiviral activities. However, other small RNA-mediated host responses may also be involved in modulating antiviral activity. The aim of this review is to summarize recent research into the nature of small RNA-mediated antiviral responses in mosquitoes and to discuss future directions for this relatively new area of research.

Indexed as

antiviral immunityarbovirusmosquitoRNAiRNA interferenceRNA silencingsmall RNAs

Identifiers

PMID26466541
PMCPMC4553608
OpenAlexW2087653761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.