ArticlePloS one2015
Effect of Bone Mineral Density on Rotator Cuff Tear: An Osteoporotic Rabbit Model.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Antiosteoporotic treatment promotes tendon-to-bone healing after rotator cuff repair : a systematic review of animal studies.Bone & joint research · 2026Pooled it
- Denosumab therapy is associated with a reduced risk of clinically diagnosed rotator cuff tears: a multi-institutional real-world cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Miacalcic Enhances Rotator Cuff Injury Healing in Osteoporotic Mice by Stimulating Neovascularization via the JAK Pathway.Mediators of inflammation · 2026Article
- The Relationship Between Bone Quality and Biomechanical Strength of All-Suture Anchors Utilized in Rotator Cuff Repairs.Orthopaedic journal of sports medicine · 2025Article
- Bioactive siRNA-Based Liposomes Promoted Tendon-Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Quantitative computed tomography analysis of bone microarchitecture is associated with rotator cuff healing.Journal of orthopaedic surgery and research · 2025Article
- Opportunistic Screening for Local Osteoporosis of the Proximal Humerus on the Basis of Hounsfield Units: A Study of Patients With Rotator Cuff Tears.Orthopaedic surgery · 2025Article
- Challenges Posed by Osteoporosis in Arthroscopy and Sports Injury Management.Indian journal of orthopaedics · 2025Review
- Osteoporosis Management for Shoulder Surgeons.Current reviews in musculoskeletal medicine · 2024Review
- Osteoporosis in the setting of rotator cuff repair: A narrative review.Shoulder & elbow · 2024Review
- The effectiveness of intravenous zoledronic acid in elderly patients with osteoporosis after rotator cuff repair: a retrospective study.Scientific reports · 2024Article
- Long-Term Effects of Reproduction and Lactation on the Rat Supraspinatus Tendon and Proximal Humerus.Journal of biomechanical engineering · 2024Article
- The Effect of Denosumab on Rotator Cuff Repair in Women Aged 60 and over with Osteoporosis: A Prospective Observational Study.Biomedicines · 2024Article
- Fast dual-echo estimation of apparent long T2 fraction using ultrashort echo time magnetic resonance imaging in tibialis tendons and its osteoporosis-related differences in women.Quantitative imaging in medicine and surgery · 2024Article
- The Relationship Among Probable SARCopenia, Osteoporosis and SuprasPinatus Tendon Tears in Postmenopausal Women: The SARCOSP Study.Calcified tissue international · 2024Article
- Bone Density Distribution Pattern in the Lateral Wall of the Femoral Intercondylar Notch: Implications for the Direct Insertion of the Femoral ACL Attachment.Orthopaedic journal of sports medicine · 2024Article
- Lower Macromolecular Content in Tendons of Female Patients with Osteoporosis versus Patients with Osteopenia Detected by Ultrashort Echo Time (UTE) MRI.Diagnostics (Basel, Switzerland) · 2022Article
- Osteoporosis increases the risk of rotator cuff tears: a population-based cohort study.Journal of bone and mineral metabolism · 2022Article
- Rotator Cuff Health, Pathology, and Repair in the Perspective of Hyperlipidemia.Journal of orthopaedics and sports medicine · 2022Article
- Trabecular Bone Score Could Not Predict the Bone Mineral Density of Proximal Humerus.Journal of bone metabolism · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionAn increased bone mineral density (BMD) in the proximity to tendon insertion can improve rotator cuff repair and healing. However, how a decrease of BMD in the humeral head affects the biomechanical properties of the rotator cuff tendon is still unclear. Previous studies have demonstrated ovariectomy in animals to lead to osteoporosis and decreased BMD, and Teriparatide (PTH) administration to improve BMD and strength of bone. This study aimed to explore the correlation between humeral head BMD and infraspinatus (ISP) tendon insertion strength, and if an increase in bone quantity of the humeral head can improve the strength of the rotator cuff. MATERIALS AND
methodsEighteen New England white rabbits were divided into the 3 groups: Control, Ovariectomy-Saline (OVX-Saline), and Ovariectomy-PTH (OVX-PTH). The OVX-Saline group and the OVX-PTH were administered daily saline and Teriparatide injections for 8 weeks starting at 17 weeks of OVX. BMD of the humeral head was measured, the ISP tendon failure load was tested and the failure stress was calculated. One specimen from each group was used for histological analysis. Linear regression analysis was used to derive equations for the BMD and failure stress.
resultsSignificant differences were observed in the measured humeral head BMD of the Control and OVX-PTH groups compared to the OVX-Saline group (P = 0.0004 and P = 0.0024, respectively). No significant difference was found in failure stress among the three groups, but an expected trend with the control group and OVX-PTH group presenting higher failure strength compared to the OVX-Saline group. BMD at the humeral head showed a positive linear correlation with stress (r2 = 0.54). Histology results showed the superiority in OVX-PTH group ISP enthesis compared to the OVX-Saline group.
conclusionBone loss of the humeral head leads to decreased tendon/bone insertion strength of the infraspinatus tendon enthesis. Teriparatide administration can increase bone density of the humeral head and may improve the mechanical properties of the infraspinatus tendon enthesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.