ArticleEinstein (Sao Paulo, Brazil)
Chronic psychological stress and its impact on the development of aggressive breast cancer.
Article in Einstein (Sao Paulo, Brazil). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Brief Post-Surgical Stress Management Reduces Pro-Inflammatory Cytokines in Overweight and Obese Breast Cancer Patients Undergoing Primary Treatment.Frontiers in bioscience (Landmark edition) · 2022Trial
- Depression and breast cancer: research progress and prospects from an interdisciplinary perspective.Frontiers in immunology · 2026Review
- Parental loss at age birth to 21 years and daughters' breast cancer and tumor characteristics.JNCI cancer spectrum · 2025Article
- Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway.Cell stress & chaperones · 2024Article
- Sini San Inhibits Chronic Psychological Stress-Induced Breast Cancer Stemness by Suppressing Cortisol-Mediated GRP78 Activation.Frontiers in pharmacology · 2021Article
- An association between chronic life stressors prior to diagnosis of breast cancer.EXCLI journal · 2021Article
- Effects of GSTT1 and GSTM1 polymorphisms in glutathione levels and breast cancer development in Brazilian patients.Molecular biology reports · 2021Article
- The impact of intimate partner violence on breast and cervical cancer survivors in an integrated, safety-net setting.Journal of cancer survivorship : research and practice · 2020Article
- Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2.Cell death & disease · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the clinicopathological findings of women diagnosed with breast cancer and study the impact of chronic psychological stress on the pathological characteristics of these tumors.
methodsWe investigated a cohort composed of women diagnosed with breast cancer and divided into two groups. One group was categorized as presenting with chronic psychological stress (by using the Self-Reporting Questionnaire - SRQ-20). Another group of women with breast cancer, but with no previous history of chronic psychological stress, comprised the Control Group. Clinical and pathological data were assessed.
resultsWomen presenting with a history of chronic distress were significantly overweight when compared to the Control Group. Furthermore, it was observed that these stressed women also had a significant percentage of aggressive breast cancer subtype, the HER2 amplified tumor, which could be putatively associated with the loss of immunosurveillance.
conclusionOur findings suggested an interaction among chronic psychological stress, overweight, and the development of more aggressive breast tumors.
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