Evidence map›Paper›PMID 26465715›Full record

ArticleNature communications2015

Sleep disruption impairs haematopoietic stem cell transplantation in mice.

Asya Rolls, Wendy W Pang, Ingrid Ibarra, Damien Colas, Patricia Bonnavion, Ben Korin, H Craig Heller, Irving L Weissman, Luis de Lecea

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
  2. Review
  3. Growth hormone regulates the stem cell population in the growth plate.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
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  11. Article
  12. Article
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  15. Article
  16. The circadian coordination of cell biology.The Journal of cell biology · 2016
    Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Asya RollsDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA.
Wendy W PangInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA.
Ingrid IbarraInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA.
Damien ColasDepartment of Biology, Stanford University, Stanford, California 94305, USA.
Patricia BonnavionDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA.
Ben KorinRappaport Medical School, Technion, Israel Institute of Technology, Haifa 31096, Israel.
H Craig HellerDepartment of Biology, Stanford University, Stanford, California 94305, USA.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA.
Luis de LeceaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA.
Stanford University · USCalifornia Institute for Regenerative Medicine · USTechnion – Israel Institute of Technology · IL

Funding

Interrogation of individual cells to identify progenitors and their nichesU01HL099999 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2009 to 2015
$7.8M
HSC Diversity: Regulation by Clonal Selection vs Epigenetic InductionR01CA086065 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2000 to 2017
$6.9M
HOMING RECEPTOR DETERMINANTS ON HSCR01HL058770 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 1998 to 2013
$3.9M
NCI NIH HHS R01 CA086065NCI NIH HHS R01 CA86065NHLBI NIH HHS R01 HL058770NHLBI NIH HHS U01 HL099999NHLBI NIH HHS U01-HL099999-03
6 · The paper itself

Abstract

Many of the factors affecting the success of haematopoietic cell transplantation are still unknown. Here we show in mice that donor sleep deprivation reduces the ability of its haematopoietic stem cells (HSCs) to engraft and reconstitute the blood and bone marrow of an irradiated recipient by more than 50%. We demonstrate that sleep deprivation downregulates the expression of microRNA (miR)-19b, a negative regulator of the suppressor of cytokine signalling (SOCS) genes, which inhibit HSC migration and homing. Accordingly, HSCs from sleep-deprived mice have higher levels of SOCS genes expression, lower migration capacity in vitro and reduced homing to the bone marrow in vivo. Recovery of sleep after sleep deprivation restored the reconstitution potential of the HSCs. Taken together, this study provides insights into cellular and molecular mechanisms underlying the effects of sleep deprivation on HSCs, emphasizing the potentially critical role of donor sleep in the success of bone marrow transplantation.

Indexed as

Hematopoietic Stem Cell TransplantationAnimalsCell MovementGrowth HormoneHematopoietic Stem CellsMice, Inbred C57BLMice, TransgenicMicroRNAsSleep DeprivationSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsGrowth HormoneMicroRNAsMIRN19 microRNA, mouseSocs3 protein, mouseSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling Proteins

Identifiers

PMID26465715
PMCPMC4621781
OpenAlexW2267951826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.