ArticleAnalytical chemistry2015
Parts per Million Powder X-ray Diffraction.
Article in Analytical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
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- 3D printed UV-sensing optical fiber probes: manufacturing, properties, and performance.Scientific reports · 2024Article
- Microstructural, Electrical, and Tribomechanical Properties of Mo-W-C Nanocomposite Films.Nanomaterials (Basel, Switzerland) · 2024Article
- Compositional Analysis of Complex Mixtures using Automatic MicroED Data Collection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair.Regenerative medicine · 2024Article
- Material-Sparing Feasibility Screening for Hot Melt Extrusion.Pharmaceutics · 2024Article
- Exploring high-throughput synchrotron X-Ray powder diffraction for the structural analysis of pharmaceuticals.International journal of pharmaceutics: X · 2023Article
- UV polymerization fabrication method for polymer composite based optical fiber sensors.Scientific reports · 2023Article
- Impact of Gastric pH Variations on the Release of Amorphous Solid Dispersion Formulations Containing a Weakly Basic Drug and Enteric Polymers.Molecular pharmaceutics · 2023Article
- Bioadhesive 3D-Printed Skin Drug Delivery Polymeric Films: From the Drug Loading in Mesoporous Silica to the Manufacturing Process.Pharmaceutics · 2022Article
- Mechanism and principle of doping: realizing of silver incorporation in CdS thin filmRSC advances · 2022Article
- Microstructure and Corrosion Behavior of Sn-Zn Alloys.Materials (Basel, Switzerland) · 2022Article
- Novel TiOMembranes · 2022Article
- A holistic approach to lead pipe scale analysis: Importance, methodology, and limitations.AWWA water science · 2022Article
- Niclosamide inhalation powder made by thin-film freezing: Multi-dose tolerability and exposure in rats and pharmacokinetics in hamsters.International journal of pharmaceutics · 2021Article
- Controlled Synthesis of Large Single Crystals of Metal-Organic Framework CPO-27-Ni Prepared by a Modulation Approach: In situ Single-Crystal X-ray Diffraction Studies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Using X-ray Diffraction Techniques for Biomimetic Drug Development, Formulation, and Polymorphic Characterization.Biomimetics (Basel, Switzerland) · 2020Review
- Nanocrystalline Electrodeposited Fe-W/AlFrontiers in chemistry · 2019Article
- Probing molecule-like isolated octahedra via-phase stabilization of zero-dimensional cesium lead halide nanocrystals.Nature communications · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Here we demonstrate the use of second harmonic generation (SHG) microscopy-guided synchrotron powder X-ray diffraction (PXRD) for the detection of trace crystalline active pharmaceutical ingredients in a common polymer blend. The combined instrument is capable of detecting 100 ppm crystalline ritonavir in an amorphous hydroxypropyl methylcellulose matrix with a high signal-to-noise ratio (>5000). The high spatial resolution afforded by SHG microscopy allows for the use of a minibeam collimator to reduce the total volume of material probed by synchrotron PXRD. The reduction in probed volume results in reduced background from amorphous material. The ability to detect low crystalline loading has the potential to improve measurements in the formulation pipeline for pharmaceutical solid dispersions, for which even trace quantities of crystalline active ingredients can negatively impact the stability and bioavailability of the final drug product.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.