ArticleeNeuro
Dynamic Input Conductances Shape Neuronal Spiking
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Inward rectifier potassium channels interact with calcium channels to promote robust and physiological bistability.PLoS computational biology · 2026Article
- Fast reconstruction of degenerate populations of conductance-based neuron models from spike times.PLoS computational biology · 2026Article
- Activity-dependent neuromodulation and calcium homeostasis cooperate to produce robust and modulable neuronal function.PLoS computational biology · 2026Article
- Rapid, interpretable data-driven models of neural dynamics using recurrent mechanistic models.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dimensionality reduction of neuronal degeneracy reveals two interfering physiological mechanisms.PNAS nexus · 2024Article
- Robust switches in thalamic network activity require a timescale separation between sodium and T-type calcium channel activations.PLoS computational biology · 2021Article
- Neuronal oscillator robustness to multiple global perturbations.Biophysical journal · 2021Article
- Polynomial, piecewise-Linear, Step (PLS): A Simple, Scalable, and Efficient Framework for Modeling Neurons.Frontiers in neuroinformatics · 2021Article
- Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Switchable slow cellular conductances determine robustness and tunability of network states.PLoS computational biology · 2018Article
- Robust and tunable bursting requires slow positive feedback.Journal of neurophysiology · 2018Article
- Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance.Current opinion in neurobiology · 2016Review
- A positive feedback at the cellular level promotes robustness and modulation at the circuit level.Journal of neurophysiology · 2015Article
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Authors and funding
4 authors.
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Abstract
Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness, and homeostasis of neuronal signalling. The paper proposes that this question can be addressed through the analysis of dynamic input conductances. Those voltage-dependent curves aggregate the concomitant activity of all ion channels in distinct timescales. They are shown to shape the current-voltage dynamical relationships that determine neuronal spiking. We propose an experimental protocol to measure dynamic input conductances in neurons. In addition, we provide a computational method to extract dynamic input conductances from arbitrary conductance-based models and to analyze their sensitivity to arbitrary parameters. We illustrate the relevance of the proposed approach for modulation, compensation, and robustness studies in a published neuron model based on data of the stomatogastric ganglion of the crab Cancer borealis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.