ArticleCell journal2015
Salivary Interferon Gamma and Interleukin-4 Levels in Patients Suffering from Oral Lichen Planus.
Article in Cell journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Role of interleukin-4 in pathogenesis of oral lichen planus: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- The role of vitamin D in amelioration of oral lichen planus and its effect on salivary and tissue IFN-γ level: a randomized clinical trial.BMC oral health · 2024Trial
- Natural and induced immune responses in oral cavity and saliva.BMC immunology · 2025Review
- Article
- Paeoniflorin drives the immunomodulatory effects of mesenchymal stem cells by regulating Th1/Th2 cytokines in oral lichen planus.Scientific reports · 2022Article
- Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What's New?International journal of molecular sciences · 2022Review
- Salivary cytokine profile in patients with oral lichen planus.Journal of dental sciences · 2022Article
- Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment.Frontiers in immunology · 2022Review
- Oral lichen planus: a microbiologist point of view.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Review
- Interleukin-6 released by oral lichen planus myofibroblasts promotes angiogenesis.Experimental and therapeutic medicine · 2021Article
- Presence of B Cells and Plasma Cells in Oral Lichen Planus.Journal of dentistry (Shiraz, Iran) · 2020Article
- Cytokines Levels and Salivary Microbiome Play A Potential Role in Oral Lichen Planus Diagnosis.Scientific reports · 2019Article
- Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis.Clinical and experimental dental research · 2017Article
- Recognizing the salivary panomics for the clinical application in oral potentially malignant disorders.Journal of oral and maxillofacial pathology : JOMFPReview
- Convergence of inflammatory response: Salivary cytokine dynamics in coronavirus disease 2019 and periodontal disease.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOral lichen planus (OLP) is a chronic inflammatory disease. Immunological factor may act as etiological factor. The cellular immune cells such as T cells are impor- tant in pathogenesis. Interferon gamma (IFN-γ) and interleukin 4 (IL-4) are secreted by T-helper 1 (Th1) and Th2, respectively. The aim of this study was to investigate the cor- relation between salivary levels of IFN-γ and IL-4 with OLP. MATERIALS AND
methodsThis case control study included sixty three Iranian OLP patients who were selected from the Department of Oral Medicine of Ahvaz Jundishapur University of Medical Sciences from January to July 2013. An equal number of healthy volunteers were also selected as a control group. The OLP patients were then divided into two follow- ing sub-groups: reticular (n=30) and erythematous/ulcerative (n=33). All patients had no systemic disease and received no medication. IFN-γ and IL-4 levels in whole unstimulated saliva (WUS) were measured using the enzyme-linked immunosorbent assay (ELISA) test. Data analysis was done using t test, ANOVA, least significant difference (LSD) test, and the Kruskal-Wallis test.
resultsReticular OLP patients showed higher salivary IFN-γ (7.74 ± 0.09 pg/ml ) and IL-4 (3.876 ± 0.05 pg/ml) levels compared with the control group, indicating that difference was significant. Salivary IFN-γ/IL-4 ratio significantly increased compared with control group (P=0.042). Salivary IFN-γ and IL-4 levels between sub-groups (re- ticular and erythematous/ulcerative) were not significantly different (2.6 ± 0.06 and 2.3 ± 0.05, respectively, P<0.05).
conclusionSalivary IFN-γ and IL-4 levels were increased in OLP patients. An increase of salivary IFN-γ/IL-4 ratio in OLP patients showed that Th1 might have a dominant role in the OLP pathogenesis.
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