Evidence map›Paper›PMID 26464804›Full record

ArticleBMJ open diabetes research & care2015

Challenges of diabetes prevention in the real world: results and lessons from the Melbourne Diabetes Prevention Study.

James A Dunbar, Andrea L Hernan, Edward D Janus, Erkki Vartiainen, Tiina Laatikainen, Vincent L Versace, John Reynolds, James D Best, Timothy C Skinner, Sharleen L O'Reilly and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open diabetes research & care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

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  14. How do we identify people at high risk of Type 2 diabetes and help prevent the condition from developing?Diabetic medicine : a journal of the British Diabetic Association · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

James A DunbarFaculty of Health , Deakin Population Health Strategic Research Centre, Deakin University, Melbourne Burwood Campus , Burwood, Victoria , Australia.
Andrea L HernanGreater Green Triangle University Department of Rural Health , Flinders and Deakin Universities , Warrnambool, Victoria , Australia.
Edward D JanusGreater Green Triangle University Department of Rural Health , Flinders and Deakin Universities , Warrnambool, Victoria , Australia ; Western Academic Centre, Western Centre for Health Research and Education, Western Health, University of Melbourne , St. Albans, Victoria , Australia.
Erkki VartiainenGreater Green Triangle University Department of Rural Health , Flinders and Deakin Universities , Warrnambool, Victoria , Australia ; National Institute for Health and Welfare , Helsinki , Finland.
Tiina LaatikainenGreater Green Triangle University Department of Rural Health , Flinders and Deakin Universities , Warrnambool, Victoria , Australia ; National Institute for Health and Welfare , Helsinki , Finland ; Faculty of Health Sciences , Institute of Public Health and Clinical Nutrition, University of Eastern Finland , Kuopio , Finland.
Vincent L VersaceGreater Green Triangle University Department of Rural Health , Flinders and Deakin Universities , Warrnambool, Victoria , Australia.
John ReynoldsFaculty of Medicine, Nursing and Health Sciences , Monash University , Melbourne, Victoria , Australia.
James D BestLee Kong Chian School of Medicine, Nanyang Technological University and Imperial College London , Singapore , Singapore.
Timothy C SkinnerSchool of Psychological and Clinical Sciences, Charles Darwin University , Darwin, Northern Territory , Australia.
Sharleen L O'ReillyCentre for Physical Activity and Nutrition Research, Deakin University, Melbourne Burwood Campus , Burwood, Victoria , Australia.
Kevin P Mc NamaraGreater Green Triangle University Department of Rural Health , Flinders and Deakin Universities , Warrnambool, Victoria , Australia ; Faculty of Pharmacy and Pharmaceutical Sciences , Centre for Medicine Use and Safety, Monash University , Parkville, Victoria , Australia.
Elizabeth StewartFaculty of Health , Deakin Population Health Strategic Research Centre, Deakin University, Melbourne Burwood Campus , Burwood, Victoria , Australia.
Michael CoatesGreater Green Triangle University Department of Rural Health , Flinders and Deakin Universities , Warrnambool, Victoria , Australia.
Catherine M BennettFaculty of Health , Deakin Population Health Strategic Research Centre, Deakin University, Melbourne Burwood Campus , Burwood, Victoria , Australia.
Rob CarterFaculty of Health, Deakin Health Economics , Deakin University, Melbourne Burwood Campus , Burwood, Victoria , Australia.
Deakin University · AUFinnish Institute for Health and Welfare · FIMonash University · AUCharles Darwin University · AUNanyang Technological University · SGWestern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess effectiveness and implementability of the public health programme Life! Taking action on diabetes in Australian people at risk of developing type 2 diabetes. RESEARCH DESIGN AND

methodsMelbourne Diabetes Prevention Study (MDPS) was a unique study assessing effectiveness of Life! that used a randomized controlled trial design. Intervention participants with AUSDRISK score ≥15 received 1 individual and 5 structured 90 min group sessions. Controls received usual care. Outcome measures were obtained for all participants at baseline and 12 months and, additionally, for intervention participants at 3 months. Per protocol set (PPS) and intention to treat (ITT) analyses were performed.

resultsPPS analyses were considered more informative from our study. In PPS analyses, intervention participants significantly improved in weight (-1.13 kg, p=0.016), waist circumference (-1.35 cm, p=0.044), systolic (-5.2 mm Hg, p=0.028) and diastolic blood pressure (-3.2 mm Hg, p=0.030) compared with controls. Based on observed weight change, estimated risk of developing diabetes reduced by 9.6% in the intervention and increased by 3.3% in control participants. Absolute 5-year cardiovascular disease (CVD) risk reduced significantly for intervention participants by 0.97 percentage points from 9.35% (10.4% relative risk reduction). In control participants, the risk increased by 0.11 percentage points (1.3% relative risk increase). The net effect for the change in CVD risk was -1.08 percentage points of absolute risk (p=0.013).

conclusionsMDPS effectively reduced the risk of diabetes and CVD, but the intervention effect on weight and waist reduction was modest due to the challenges in recruiting high-risk individuals and the abbreviated intervention.

Indexed as

Cardiovascular PreventionInterventionPublic HealthType 2 Diabetes

Identifiers

PMID26464804
PMCPMC4597415
OpenAlexW2320155394

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.