Evidence map›Paper›PMID 26464724›Full record

ArticleInternational journal of clinical and experimental pathology2015

CX3CR1 polymorphisms and the risk of age-related macular degeneration.

Baofeng Ma, Guangfu Dang, Shaoyuan Yang, Lian Duan, Yanwei Zhang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. The CX3CL1-CX3CR1 axis in HIV-associated inflammation and cardiometabolic disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Review
  2. Article
  3. Association betweenMolecular biology research communications · 2023
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Polymorphisms in Selected Genes and Their Association with Age-Related Macular Degeneration in a Chinese Population.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  11. Article
  12. Risk factors and biomarkers of age-related macular degeneration.Progress in retinal and eye research · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Baofeng MaDepartment of Ophthalmology, Shandong Provincial Qianfoshan Hospital, Shandong University Jinan 250014, Shandong, China.
Guangfu DangDepartment of Ophthalmology, Shandong Provincial Qianfoshan Hospital, Shandong University Jinan 250014, Shandong, China.
Shaoyuan YangDepartment of Ophthalmology, Shandong Provincial Qianfoshan Hospital, Shandong University Jinan 250014, Shandong, China.
Lian DuanDepartment of Ophthalmology, Shandong Provincial Qianfoshan Hospital, Shandong University Jinan 250014, Shandong, China.
Yanwei ZhangDepartment of Ophthalmology, Shandong Provincial Qianfoshan Hospital, Shandong University Jinan 250014, Shandong, China.
Shandong Provincial QianFoShan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-related macular degeneration (AMD), a most common eye disease, can lead to irreversible visual impairment. Age, genetic and environmental factors have been implicated in AMD. Chemokine (C-X3-C motif) receptor 1 (CX3CR1) gene polymorphisms could influence the susceptibility of AMD.

methodsWe tested the association between AMD and single nocleotide polymorphisms (SNPs) of CX3CR1 gene (rs3732378 and rs3732379) in 102 cases and 115 controls from China. Genotypes were determined by MassArray genotyping assay method. Association between CX3CR1 gene polymorphisms and AMD were examined by χ(2) test and logistic regression.

resultsGenotype distribution of CX3CR1 gene polymorphisms were in accordance with HWE examination. No obvious differences were observed in the genotypes of rs3732378 polymorphism between case and control groups (P>0.05), but A allele of it could increase the risk of AMD (P=0.025, OR=2.391, 95% CI=1.092-5.237). Both TT genotype and T allele of rs3732379 were significantly associated with the susceptibility of AMD (P=8.663, OR=8.663, 95% CI=1.044-71.874; P=0.021, OR=2.076, 95% CI=1.104-3.903). Age, gender and smoking status were used as common confounders to adjust the association between CX3CR1 gene polymorphism and AMD risk. Then we found that rs3732378 had no obvious association with AMD susceptibility. TT genotype of rs3732379 related to the occurrence of AMD, but the association was not significant (P=0.050, OR=8.274, 95% CI=1.002-69.963). T allele of rs3732379 might increase the susceptibility of AMD (P=0.029, OR=2.033, 95% CI=1.077-3.838).

conclusionT allele of rs3732379 might have a positive association with the susceptibility of AMD.

Indexed as

Polymorphism, Single NucleotideAgedCX3C Chemokine Receptor 1FemaleGenetic Predisposition to DiseaseGenotypeHumansMacular DegenerationMaleMiddle AgedReceptors, ChemokineRisk FactorsCX3C Chemokine Receptor 1CX3CR1 protein, humanReceptors, ChemokineAge-related macular degenerationCX3CR1 genepolymorphisms

Identifiers

PMID26464724
PMCPMC4583956
OpenAlexW2413676444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.