ArticleInternational journal of clinical and experimental pathology2015
Association of four common SNPs in microRNA polymorphisms with the risk of hepatocellular carcinoma.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- MiRNA Polymorphisms and Hepatocellular Carcinoma Susceptibility: A Systematic Review and Network Meta-Analysis.Frontiers in oncology · 2020Pooled it
- Association of mir-196a-2 rs11614913 and mir-149 rs2292832 Polymorphisms With Risk of Cancer: An Updated Meta-Analysis.Frontiers in genetics · 2019Pooled it
- Comprehensive assessment for miRNA polymorphisms in hepatocellular cancer risk: a systematic review and meta-analysis.Bioscience reports · 2018Pooled it
- Pooled it
- [Association between miR-146a single nucleotide polymorphism and genetic susceptibility to hepatocellular carcinoma: a meta-analysis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017Pooled it
- Genetic association of miR-146a, miR-196a2, and miR-499 polymorphisms with hepatocellular carcinoma risk in an Eastern Chinese population.Frontiers in oncology · 2026Article
- The Association between Four Common Polymorphisms in microRNA and Risk of Hepatocellular Carcinoma: An Updated Meta-Analysis.Iranian journal of public health · 2023Review
- Analysis of miRNA expression profiles in exosomes of SMB-S15 cells treated with resveratrol.Archives of virology · 2023Article
- Rs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma: A meta-analysis 14812 subjects.World journal of gastrointestinal oncology · 2023Article
- Association between SNPs in microRNAs and microRNAs-Machinery Genes with Susceptibility of Leprosy in the Amazon Population.International journal of molecular sciences · 2022Article
- The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients.Archives of medical science : AMS · 2022Article
- Association of MicroRNA 196a and 499 Polymorphisms with Development of Cirrhosis and Hepatocellular Carcinoma Post-HCV Infection in Egyptian Patients.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population.Journal of thrombosis and thrombolysis · 2019Article
- Article
- rs11614913 polymorphism in miRNA-196a2 and cancer risk: an updated meta-analysis.OncoTargets and therapy · 2018Review
- A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies.Frontiers in physiology · 2018Article
- MicroRNA-Related Polymorphisms in Infectious Diseases-Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications.Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a case-control study to investigate genetic variants of miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs2292832 and miR-499 rs3746444 in the development of HCC in a Chinese population. This case-control study included 266 HCC patients and 266 control subjects between January 2012 and December 2013. Conditional logistical regression analysis indicated that TT genotype and T allele of miR-196a2 rs11614913 carried a 2.29-fold (95% CI = 1.30-4.05) and 1.60-fold (95% CI = 1.11-2.32) increased risk of HCC when compared with CC genotype, respectively. The subgroup analysis indicated that the effect of miR-196a2 rs11614913 polymorphism was influence by HBV infection. HBV infection subjects carrying the CT + TT genotype of miR-196a2 rs11614913 had an increased risk of HCC, and the OR (95% CI) was 2.89 (1.19-7.02). In conclusion, miR-196a2 rs11614913 polymorphism may contribute to identifying individuals, especially in HBV-infected subjects, who are at high risk for HCC.
Indexed as
Identifiers
26464719PMC4583951W2415986806What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.