ArticleInternational journal of clinical and experimental pathology2015
MiR-451, a potential prognostic biomarker and tumor suppressor for gastric cancer.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis.Oncotarget · 2017Pooled it
- Unraveling the therapeutic landscape of miRNAs in pancreatic cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Review
- Diagnostic and prognostic value of miR-486-5p, miR-451a, miR-21-5p and monocyte to high-density lipoprotein cholesterol ratio in patients with acute myocardial infarction.Heart and vessels · 2023Article
- Downregulation of miR-451 in cholangiocarcinoma help the diagnsosi and promotes tumor progression.BMC molecular and cell biology · 2022Article
- Article
- Clinical Potential of miR-451 and miR-506 as a Prognostic Biomarker in Patients with Breast Cancer.Journal of healthcare engineering · 2022Article
- Micro-RNA-451 Reduces Proliferation of B-CPAP Human Papillary Thyroid Cancer Cells by Downregulating Expression of Activating Transcription Factor 2.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Suppression of HELLS by miR-451a represses mTOR pathway to hinder aggressiveness of SCLC.Genes & genomics · 2021Article
- ssc-miR-451 Regulates Porcine Primary Adipocyte Differentiation by Targeting ACACA.Animals : an open access journal from MDPI · 2020Article
- Knockdown of lncRNA SNHG12 suppresses cell proliferation, migration and invasion in breast cancer by sponging miR-451a.International journal of clinical and experimental pathology · 2020Article
- MicroRNA-451a targets caveolin-1 in stomach cancer cells.International journal of clinical and experimental pathology · 2020Article
- MicroRNA signature refine response prediction in CML.Scientific reports · 2019Article
- MiR-451 suppresses the growth, migration, and invasion of prostate cancer cells by targeting macrophage migration inhibitory factor.Translational cancer research · 2019Article
- MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer.Cell death & disease · 2019Article
- Swimming prevents nonalcoholic fatty liver disease by reducing migration inhibitory factor through Akt suppression and autophagy activation.American journal of translational research · 2019Article
- Plasma Level Of miR-21 And miR-451 In Primary And Recurrent Breast Cancer Patients.Breast cancer (Dove Medical Press) · 2019Article
- miR-451: A Novel Biomarker and Potential Therapeutic Target for Cancer.OncoTargets and therapy · 2019Review
- MicroRNA-23a/27a/24-2 cluster promotes gastric cancer cell proliferation synergistically.Oncology letters · 2018Article
- Expression profile of circulating microRNAs in the Correa pathway of progression to gastric cancer.United European gastroenterology journal · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe expression of microRNA-451 (miR-451) and its association with clinical pathological factors in GC remain still unclear. The purpose of this study was to investigate if miR-451 is a potential prognostic biomarker and tumor suppressor for gastric cancer.
methodsReal-time quantitative RT-PCR (qRT-PCR) was applied to detect miR-451 expression in GC cell lines and primary tumor and paired non-cancerous tissues. The association of miR-451 expression with clinicopathological factors and prognosis was statistically analyzed.
resultsWe found that miR-451 showed decreased expression in GC tissues and cell lines, and its down-regulation tended to be positively correlated with lymphatic metastasis, clinical staging and shorter overall survival of patients. In addition, forced expression of miR-451 in BGC-823 and MKN-45 cells did not impact on cell proliferation, but did reduce migration and invasion rates in BGC-823 cells.
conclusionOur findings indicated that miR-451 may act as a novel prognostic marker and potential therapeutic target in human GC.
Indexed as
Identifiers
26464660PMC4583892W2418986838What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.