ArticleThe open microbiology journal2015
Iron Acquisition Mechanisms: Promising Target Against Mycobacterium tuberculosis.
Article in The open microbiology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- TargetingRSC medicinal chemistry · 2023Review
- Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Interferon-gamma promotes iron export in human macrophages to limit intracellular bacterial replication.PloS one · 2020Article
- Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.Scientific reports · 2019Article
- Iron Supplementation Therapy, A Friend and Foe of Mycobacterial Infections?Pharmaceuticals (Basel, Switzerland) · 2019Review
- Understanding lipidomic basis of iron limitation induced chemosensitization of drug-resistant3 Biotech · 2019Article
- Bioinformatic Exploration of Metal-Binding Proteome of Zoonotic PathogenFrontiers in genetics · 2019Article
- Iron homeostasis in Mycobacterium tuberculosis is essential for persistence.Scientific reports · 2018Article
- The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays.Scientific reports · 2017Article
- Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity.Journal of pathogens · 2015Article
- Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis.Indian journal of pharmacologyReview
- Influence of iron deprivation on virulence traits of mycobacteria.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous deployment of antitubercular drugs in treating Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed as Multi-Drug Resistance (MDR-TB). Despite reasonable documentation of major factors which contribute to MDR mechanisms, it appears unavoidable to consider novel mechanisms combating MDR. The ability of pathogenic MTB, to sense and become accustomed to changes in the host environment is essential for its survival and confers the basis of their success as dreadful pathogen. One such significant environmental factor that MTB must surmount is iron limitation, since they encounter diverse anatomical sites during the establishment of infection within the host. Considering the importance of MTB, being the second most common cause of mortality, this review focuses on gaining insights of iron acquisition mechanisms in MTB and how it can be exploited as efficient anti-mycobacterial drug target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.