ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015
Breast Cancer Risk in Relation to Ambient Air Pollution Exposure at Residences in the Sister Study Cohort.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 9 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 9 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Impact of Pollution on Cancer: A Systematic Review and Meta-Analysis with Focus on Air Pollution.International journal of environmental research and public health · 2026Pooled it
- Ambient Air Pollution Exposure and Breast Cancer Risk Worldwide: A Systematic Review of Longitudinal Studies.International journal of environmental research and public health · 2024Pooled it
- Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis.JCO global oncology · 2024Pooled it
- Association between long-term ambient air pollution exposure and the risk of breast cancer: a systematic review and meta-analysis.Environmental science and pollution research international · 2021Pooled it
- Breast Cancer Risk in Association with Atmospheric Pollution Exposure: A Meta-Analysis of Effect Estimates Followed by a Health Impact Assessment.Environmental health perspectives · 2021Pooled it
- Relationship between particulate matter exposure and female breast cancer incidence and mortality: a systematic review and meta-analysis.International archives of occupational and environmental health · 2021Pooled it
- Environmental exposures and breast cancer risk in the context of underlying susceptibility: A systematic review of the epidemiological literature.Environmental research · 2020Pooled it
- The relationship between exposure to particulate matter and breast cancer incidence and mortality: A meta-analysis.Medicine · 2019Pooled it
- Is breast cancer a result of epigenetic responses to traffic-related air pollution? A review of the latest evidence.Epigenomics · 2019Pooled it
- Air pollution and breast cancer incidence in a United States-wide prospective cohort study: Examining sensitive periods of exposure.Environment international · 2025Article
- Residential proximity to national priorities list superfund sites is associated with increased likelihood of metastatic breast cancer presentation.Scientific reports · 2025Article
- Association between nitrogen dioxide and incident breast cancer in Alberta's tomorrow project.Scientific reports · 2025Article
- Air Pollution and Breast Cancer Incidence in the Multiethnic Cohort Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
- The recurrence and mortality risk in Luminal A breast cancer patients who lived in high pollution area.PloS one · 2025Article
- Ambient polycyclic aromatic hydrocarbon exposure and breast cancer risk in a population-based Canadian case-control study.Cancer causes & control : CCC · 2024Article
- Outdoor air pollution exposure and uterine cancer incidence in the Sister Study.Journal of the National Cancer Institute · 2024Article
- Exposure to outdoor ambient air toxics and risk of breast cancer: The multiethnic cohort.International journal of hygiene and environmental health · 2024Article
- Associations of Exposure to Air Pollution during the Male Programming Window and Mini-Puberty with Anogenital Distance and Penile Width at Birth and at 1 Year of Age in the Multicenter U.S. TIDES Cohort.Environmental health perspectives · 2023Article
- Additive effects of 10-year exposures to PMEnvironmental epidemiology (Philadelphia, Pa.) · 2023Article
- Outdoor air pollution and histologic composition of normal breast tissue.Environment international · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSome but not all past studies reported associations between components of air pollution and breast cancer, namely fine particulate matter ≤2.5 μm (PM2.5) and nitrogen dioxide (NO2). It is yet unclear whether risks differ according to estrogen receptor (ER) and progesterone receptor (PR) status.
methodsThis analysis includes 47,591 women from the Sister Study cohort enrolled from August 2003 to July 2009, in whom 1,749 invasive breast cancer cases arose from enrollment to January 2013. Using Cox proportional hazards and polytomous logistic regression, we estimated breast cancer risk associated with residential exposure to NO2, PM2.5, and PM10.
resultsAlthough breast cancer risk overall was not associated with PM2.5 [HR = 1.03; 95% confidence intervals (CI), 0.96-1.11], PM10 (HR = 0.99; 95% CI, 0.98-1.00), or NO2 (HR = 1.02; 95% CI, 0.97-1.07), the association with NO2 differed according to ER/PR subtype (P = 0.04). For an interquartile range (IQR) difference of 5.8 parts per billion (ppb) in NO2, the relative risk (RR) of ER(+)/PR(+) breast cancer was 1.10 (95% CI, 1.02-1.19), while there was no evidence of association with ER(-)/PR(-) (RR = 0.92; 95% CI, 0.77-1.09; Pinteraction = 0.04).
conclusionsWithin the Sister Study cohort, we found no significant associations between air pollution and breast cancer risk overall. But we observed an increased risk of ER(+)/PR(+) breast cancer associated with NO2. IMPACT: Though these results suggest there is no substantial increased risk for breast cancer overall in relation to air pollution, NO2, a marker of traffic-related air pollution, may differentially affect ER(+)/PR(+) breast cancer.
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