ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2015
Clinical severity of pediatric respiratory illness with enterovirus D68 compared with rhinovirus or other enterovirus genotypes.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Likelihood of hospitalization for a chronic respiratory condition following pediatric infection with enterovirus and rhinovirus strains.Infectious medicine · 2022Article
- Enterovirus D68 respiratory infection in a children's hospital in Japan in 2015.Pediatrics international : official journal of the Japan Pediatric Society · 2019Article
- The Fraction of Rhinovirus Detections Attributable to Mild and Severe Respiratory Illness in a Setting of High Human Immunodeficiency Virus Prevalence, South Africa, 2013-2015.The Journal of infectious diseases · 2019Article
- Enterovirus D-68 in children presenting for acute care in the hospital setting.Influenza and other respiratory viruses · 2018Article
- Severe Respiratory Illness Associated With Rhinovirus During the Enterovirus D68 Outbreak in the United States, August 2014-November 2014.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Andrographolide Prevents EV-D68 Replication by Inhibiting the Acidification of Virus-Containing Endocytic Vesicles.Frontiers in microbiology · 2018Article
- Enterovirus D68-Associated Community-Acquired Pneumonia in the Pediatric Age Group.Current infectious disease reports · 2017Review
- What happened to enterovirus D68 infections in 2015?Canada communicable disease report = Releve des maladies transmissibles au Canada · 2016Article
- Enterovirus D68 in Hospitalized Children: Sequence Variation, Viral Loads and Clinical Outcomes.PloS one · 2016Article
- Respiratory Presentation of Pediatric Patients in the 2014 Enterovirus D68 Outbreak.Canadian respiratory journal · 2016Article
- Enterovirus D68 and disease severity: more questions than answers.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2015Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEnterovirus D68 (EV-D68) resulted in a reported increase in the number of children needing hospital or critical care admission because of respiratory insufficiency during 2014. It remains unclear, however, whether EV-D68 infections were more severe than rhinovirus or non-EV-D68 enterovirus infections.
methodsWe evaluated consecutive children presenting to a pediatric hospital between Aug. 1 and Oct. 31, 2014, with positive nasopharyngeal swabs for rhinovirus or enterovirus that were sent automatically for EV-D68 testing. We compared characteristics and outcomes of patients with EV-D68 with those with rhinovirus or non-EV-D68 enterovirus in a matched cohort study.
resultsA total of 93/297 (31.3%) of rhinovirus or enterovirus samples tested positive for EV-D68, and it was possible to compare 87 matched pairs. Children with EV-D68 infection were more likely to have difficulty breathing (odds ratio [OR] 3.00, 95% confidence interval [CI] 1.47-6.14). There was no significant difference in admission to the critical care unit or death among children with EV-D68 infection compared with those with other rhinovirus or enterovirus infections (adjusted OR 1.47, 95% CI 0.61-3.52). Children with EV-D68 infection were more often admitted to hospital, but not significantly so (adjusted OR 2.29, 95% CI 0.96-5.46).
interpretationEnterovirus D68 seems to be a more virulent pulmonary pathogen than rhinovirus or non-EV-D68 enterovirus, but we did not find a significant difference in death or need for critical care.
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