Evidence map›Paper›PMID 26464101›Full record

ArticleJournal of neurology2015

Antisaccade errors reveal cognitive control deficits in Parkinson's disease with freezing of gait.

Courtney C Walton, Claire O'Callaghan, Julie M Hall, Moran Gilat, Loren Mowszowski, Sharon L Naismith, James R Burrell, James M Shine, Simon J G Lewis

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Eye movement abnormalities in movement disorders.Clinical parkinsonism & related disorders · 2019
    Review
  18. The Relationship between Saccades and Locomotion.Journal of movement disorders · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Courtney C WaltonParkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, NSW, Australia.
Claire O'CallaghanParkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, NSW, Australia.
Julie M HallParkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, NSW, Australia.
Moran GilatParkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, NSW, Australia.
Loren MowszowskiParkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, NSW, Australia.
Sharon L NaismithParkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, NSW, Australia.
James R BurrellNeuroscience Research Australia, University of New South Wales, Sydney, NSW, Australia.
James M ShineNeuroscience Research Australia, University of New South Wales, Sydney, NSW, Australia.
Simon J G LewisParkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, NSW, Australia. simonl@med.usyd.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Freezing of gait is a poorly understood symptom of Parkinson's disease (PD) that is commonly accompanied by executive dysfunction. This study employed an antisaccade task to measure deficits in inhibitory control in patients with freezing, and to determine if these are associated with a specific pattern of grey matter loss using voxel-based morphometry. PD patients with (n = 15) and without (n = 11) freezing along with 10 age-matched controls were included. A simple prosaccade task was administered, followed by a second antisaccade task that required subjects to either look towards or away from a peripheral target. Behavioral results from the antisaccade task were entered as covariates in the voxel-based morphometry analysis. Patient and control groups performed equally well on the first task. However, patients with freezing were significantly worse on the second, which was driven by a specific impairment in suppressing their responses toward the target on the antisaccade trials. Impaired antisaccade performance was associated with grey matter loss across bilateral visual and fronto-parietal regions. These results suggest that patients with freezing have a significant deficit of inhibitory control that is associated with volume reductions in regions crucial for orchestrating both complex motor behaviors and cognitive control. These findings highlight the inter-relationship between freezing of gait and cognition and confirm that dysfunction along common neural pathways is likely to mediate the widespread cognitive dysfunction that emerges with this symptom.

Indexed as

AgedExecutive FunctionFemaleGait Disorders, NeurologicGray MatterHumansMaleMiddle AgedParkinson DiseasePsychomotor PerformanceSaccadesAntisaccadesCognitive controlFreezing of gaitParkinson’s disease

Identifiers

PMID26464101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.