Evidence map›Paper›PMID 26464000›Full record

Trial reportBMC anesthesiology2015

Dexmedetomidine decreases the emergence agitation in infant patients undergoing cleft palate repair surgery after general anesthesia.

Wei Peng, TieJun Zhang

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 5 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06482125 nacompletednot on this mapstarted 2024, after this paper: background citation

Emergence Agitation in Pediatrics After Dexmedetomidine vs. Sevoflurane Anesthesia: a Randomized Controlled Trial

TypeinterventionalSponsorPelita Harapan UniversityRan2024 to 2024Enrolled121ConditionsEmergence DeliriumArmsDexmedetomidine, Sevoflurane
NCT07557576 narecruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate Surgery

TypeinterventionalSponsorIva SmiljanićRan2024 to 2026Enrolled90ConditionsCleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia AssessmentArmsKetamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg, Propofol (IV) 3-4 mg/kg, Sevoflurane (Volatile Anesthetic)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wei PengDepartment of Anesthesiology, School and Hospital of Stomatology, Wuhan University, No. 237 Luoyu Street, Wuhan, Hubei, 430079, China. weipeng9512@163.com.
TieJun ZhangDepartment of Anesthesiology, School and Hospital of Stomatology, Wuhan University, No. 237 Luoyu Street, Wuhan, Hubei, 430079, China. tiejunzhang23@yeah.net.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine whether continuous intravenous infusion of dexmedetomidine (DEX) can affect the incidence of Emergence Agitation (EA) after general anesthesia in infant undergoing cleft palate repair surgery.

methodsForty infants underwent cleft palate repair surgery under general anesthesia were randomly divided into the DEX (D) group and Placebo (P) groups. Patients in group D received continuous intravenous infusion of DEX 0.8 μg · kg-1 · min-1 after the induction. Patients in group P were administered with continuous intravenous infusion of the equivalent volume of normal saline. Both groups were induced with fentanyl 0.005 mg/Kg, propofol 2 mg/Kg and cisatracurium 0.2 mg/Kg. Anaesthesia was maintained with continuous intravenous infusion of propofol (2 mg/Kg · h), remifentanil (0.1 μg/Kg · h), and inhalation of 1 to 3 % sevoflurane.

resultThe heart rate (HR) in group P was significant higher than that in group D at the time of operation (P < 0.05), postoperative 15 min, 30 min and the time of extubation (P < 0.01). The mean arterial pressure (MAP) in group P was higher comparing with MAP in group D at the time of extubation (P < 0.05). The spontaneous eye opening times and spontaneous arm or leg motion times were longer in group D (P < 0.05). The mean agitation scores of patients in group D were significantly lower than that in group P (P < 0.01). However, the incidence of EA in group P and group D was 90 % and 15 % (P <0.05).

conclusionThe continuous intravenous infusion of DEX after induction could significantly reduce the occurrence of EA.

trial registrationThe Chinese Clinical Trial Register ChiCTR-TRC-13003865.

Indexed as

Anesthesia, GeneralAnesthesia Recovery PeriodCleft PalateDexmedetomidineHypnotics and SedativesPsychomotor AgitationChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfusions, IntravenousMaleDexmedetomidineHypnotics and Sedatives

Identifiers

PMID26464000
PMCPMC4603639
OpenAlexW1915058100

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.