Evidence map›Paper›PMID 26463876›Full record

ArticleJournal of assisted reproduction and genetics2015

Diminished ovarian reserve, premature ovarian failure, poor ovarian responder--a plea for universal definitions.

J Cohen, N Chabbert-Buffet, E Darai

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05743218 (Clinical Study of Liver Meridian in the Treatment of Male Impotence and Female Premature Ovarian Failure), which is not on this map. Cited by 134 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05743218 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Clinical Study of Liver Meridian in the Treatment of Male Impotence and Female Premature Ovarian Failure

TypeinterventionalSponsorThe First Affiliated Hospital of Hunan University of Traditional Chinese MedicineRan2023 to 2023Enrolled198ConditionsOvarian Reserve, Acupuncture Therapy, MeridianArmselectropuncture
3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  9. Health-related quality-of-life among patients with premature ovarian insufficiency: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J CohenService de Gynécologie-Obstétrique, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, GRC 6-UPMC Centre Expert en Endométriose (C3E), Université Pierre et Marie Curie Paris 6, Paris, France. drcohenjonathan@gmail.com.
N Chabbert-BuffetService de Gynécologie-Obstétrique, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, GRC 6-UPMC Centre Expert en Endométriose (C3E), Université Pierre et Marie Curie Paris 6, Paris, France.
E DaraiService de Gynécologie-Obstétrique, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, GRC 6-UPMC Centre Expert en Endométriose (C3E), Université Pierre et Marie Curie Paris 6, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDiminished ovarian reserve (DOR) is characterized by poor fertility outcomes, and it represents a major challenge in reproductive medicine. Although consensus exists on the concept of DOR, its definition remains blurry. DOR has to be distinguished from premature ovarian failure (POF) and poor ovarian responders (POR), who are clearly defined.

methodsWe performed a PubMed search with the terms "diminished ovarian reserve" and "in vitro fertilization (IVF)" to assess the homogeneity of the definition of DOR.

resultsOut of 121 articles, 14 gave a definition for DOR. Only one definition was used by two different teams (basal follicle-stimulating hormone (FSH) value >10 IU/l) and eight teams used 11 different definitions. Among those, four definitions did not include antral follicular count (AFC) and seven studies did. Two definitions included the results from a previous cycle.

conclusionsThe heterogeneity in the definition of DOR used in these studies contributes to confusing results. Hence, there is a need for a clear definition of DOR. It appears that AFC and anti-Müllerian hormone (AMH) serum levels are the most relevant criteria. One option could be the use of the following definition: (i) woman with any of the risk factors for POR and/or (ii) an abnormal ovarian reserve test (i.e., antral follicular count (AFC) <5-7 follicles or AMH <0.5-1.1 ng/ml). This hypothesis requires validation.

Indexed as

Ovarian ReserveFemaleHumansOvaryOvulation InductionPrimary Ovarian InsufficiencyTerminology as TopicAFCAMHDiminished ovarian reserveIVF

Identifiers

PMID26463876
PMCPMC4681731

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.