ArticleScientific reports2015
Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice.PLoS pathogens · 2021Article
- The Shaping of a B Cell Pool Maximally Responsive to Infections.Annual review of immunology · 2021Article
- Diagnosis of NTM active infection in lymphadenopathy patients with anti-interferon-gamma auto-antibody using inhibitory ELISA vs. indirect ELISA.Scientific reports · 2020Article
- Homeostasis and regulation of autoreactive B cells.Cellular & molecular immunology · 2020Review
- Article
- Activation of B-1 Cells Promotes Tumor Cell Killing in the Peritoneal Cavity.Cancer research · 2019Article
- Polyreactive antibodies in CLL correlate with the level of immunoglobulins not the number of B lymphocytes.Leukemia & lymphoma · 2019Article
- Polyreactive natural antibodies in transplantation.Current opinion in organ transplantation · 2017Review
- A generalized quantitative antibody homeostasis model: antigen saturation, natural antibodies and a quantitative antibody network.Clinical & translational immunology · 2017Article
- Monomeric Immunoglobulin A from Plasma Inhibits Human Th17 ResponsesFrontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Polyreactive antibodies are a major component of the natural antibody repertoire and bind to a variety of structurally unrelated molecules. These antibodies are thought to provide a first line of defense against bacterial infections and play a major role in the clearance of apoptotic cells. What triggers the secretion of these antibodies has remained an enigma. Using a surrogate assay for measuring polyreactive antibodies, we found that about 50% of serum IgM is polyreactive and that stimulation of TLR4(+/+), but not TLR4(-/-), mice resulted in a 40 fold increase in polyreactive antibodies. Stimulation of TLRs 3, 7, 9 also increased the secretion of polyreactive antibodies. Infection with a virus or tissue damage induced by a toxin similarly led to an increase in polyreactive antibodies in MyD88(+/+), but not MyD88(-/-) mice. We conclude that stimulation of TLRs is a key link in the mechanism of polyreactive antibody secretion into the circulation.
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Registered trials
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