ArticleGenes, brain, and behavior2015
Genes located in a chromosomal inversion are correlated with territorial song in white-throated sparrows.
Article in Genes, brain, and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Ancestral and local adaptation contribute to dispersal out of the Qinghai-Tibet Plateau in a bumblebee.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Massive Genomic and Transcriptomic Changes Within a Young Inversion Polymorphism in the Absence of Degeneration.Molecular ecology · 2026Article
- QTL-Based Evidence of Population Genetic Divergence in Male Territorial Aggressiveness of the Japanese Freshwater Threespine Stickleback.Ecology and evolution · 2025Article
- Assessing the Association Between Animal Color and Behavior: A Meta-Analysis of Experimental Studies.Ecology and evolution · 2024Article
- Repeated evolution on oceanic islands: comparative genomics reveals species-specific processes in birds.BMC ecology and evolution · 2024Article
- Adaptive expansion of ERVK solo-LTRs is associated with Passeriformes speciation events.Nature communications · 2024Article
- Allele-specific cis-regulatory methylation of the gene for vasoactive intestinal peptide in white-throated sparrows.Genes, brain, and behavior · 2022Article
- Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows.eLife · 2022Article
- Supergenes on steroids.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Expression of oxytocin receptors in the zebra finch brain during vocal development.Developmental neurobiology · 2022Article
- Genome-wide variation in DNA methylation linked to developmental stage and chromosomal suppression of recombination in white-throated sparrows.Molecular ecology · 2021Article
- Genetic mechanisms and correlational selection structure trait variation in a coral snake mimic.Proceedings. Biological sciences · 2021Article
- Inside the supergene of the bird with four sexes.Hormones and behavior · 2020Review
- A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Consequences of Single-Locus and Tightly Linked Genomic Architectures for Evolutionary Responses to Environmental Change.The Journal of heredity · 2020Article
- Article
- Time course of photo-induced Egr-1 expression in the hypothalamus of a seasonally breeding songbird.Molecular and cellular endocrinology · 2020Article
- Vasoactive intestinal peptide as a mediator of the effects of a supergene on social behaviour.Proceedings. Biological sciences · 2020Article
- A chromosomal inversion predicts the expression of sex steroid-related genes in a species with alternative behavioral phenotypes.Molecular and cellular endocrinology · 2019Article
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The genome of the white-throated sparrow (Zonotrichia albicollis) contains an inversion polymorphism on chromosome 2 that is linked to predictable variation in a suite of phenotypic traits including plumage color, aggression and parental behavior. Differences in gene expression between the two color morphs, which represent the two common inversion genotypes (ZAL2/ZAL2 and ZAL2/ZAL2(m) ), may therefore advance our understanding of the molecular underpinnings of these phenotypes. To identify genes that are differentially expressed between the two morphs and correlated with behavior, we quantified gene expression and terrirorial aggression, including song, in a population of free-living white-throated sparrows. We analyzed gene expression in two brain regions, the medial amygdala (MeA) and hypothalamus. Both regions are part of a 'social behavior network', which is rich in steroid hormone receptors and previously linked with territorial behavior. Using weighted gene co-expression network analyses, we identified modules of genes that were correlated with both morph and singing behavior. The majority of these genes were located within the inversion, showing the profound effect of the inversion on the expression of genes captured by the rearrangement. These modules were enriched with genes related to retinoic acid signaling and basic cellular functioning. In the MeA, the most prominent pathways were those related to steroid hormone receptor activity. Within these pathways, the only gene encoding such a receptor was ESR1 (estrogen receptor 1), a gene previously shown to predict song rate in this species. The set of candidate genes we identified may mediate the effects of a chromosomal inversion on territorial behavior.
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