ArticleScientific reports2015
Trapping toxins within lipid droplets is a resistance mechanism in fungi.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Revealing the ultrastructure of liveOpen biology · 2025Article
- Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates ofeLife · 2025Article
- The Effect of Temperature over the Growth and Biofilm Formation of the ThermotolerantJournal of fungi (Basel, Switzerland) · 2025Article
- Chiral Fluorescent Antifungal Azole Probes Detect Resistance, Uptake Dynamics, and Subcellular Distribution inJACS Au · 2024Article
- Exploring selection signatures in the divergence and evolution of lipid droplet (LD) associated genes in major oilseed crops.BMC genomics · 2024Article
- MoLrp1-mediated signaling induces nuclear accumulation of MoMsn2 to facilitate fatty acid oxidation for infectious growth of the rice blast fungus.Plant communications · 2023Article
- Label-free third harmonic generation imaging and quantification of lipid droplets in live filamentous fungi.Scientific reports · 2022Article
- The Antidepressant Sertraline Induces the Formation of Supersized Lipid Droplets in the Human PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- A Perilipin Affects Lipid Droplet Homeostasis and Aerial Hyphal Growth, but Has Only Small Effects on Virulence in the Insect Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Characterization of lipid droplets from a Taxus media cell suspension and their potential involvement in trafficking and secretion of paclitaxel.Plant cell reports · 2022Article
- Rhamnolipids and fengycins, very promising amphiphilic antifungal compounds from bacteria secretomes, act onFrontiers in microbiology · 2022Article
- Raman Study of PathogenicFrontiers in microbiology · 2022Article
- Lipid droplet evolution gives insight into polyaneuploid cancer cell lipid droplet functions.Medical oncology (Northwood, London, England) · 2021Review
- Lipid droplets and the host-pathogen dynamic: FATal attraction?The Journal of cell biology · 2021Review
- Yeasts of the Blastobotrys genus are promising platform for lipid-based fuels and oleochemicals production.Applied microbiology and biotechnology · 2021Review
- Unique Attributes of the Laurel Wilt Fungal Pathogen,Pathogens (Basel, Switzerland) · 2021Article
- Lipid Droplets Protect Aging Mitochondria and Thus Promote Lifespan in Yeast Cells.Frontiers in cell and developmental biology · 2021Article
- Polarization-sensitive stimulated Raman scattering imaging resolves amphotericin B orientation inScience advances · 2021Article
- Solid-state NMR spectroscopy identifies three classes of lipids inThe Journal of biological chemistry · 2020Article
- Exposure ofFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid droplets (LDs) act as intracellular storage organelles in most types of cells and are principally involved in energy homeostasis and lipid metabolism. However, the role of LDs in resistance to toxins in fungi remains largely unknown. Here, we show that the trapping of endogenous toxins by LDs is a self-resistance mechanism in the toxin producer, while absorbing external lipophilic toxins is a resistance mechanism in the toxin recipient that acts to quench the production of reactive oxygen species. We found that an endolichenic fungus that generates phototoxic perylenequinones (PQs) trapped the PQs inside LDs. Using a model that incorporates the fungicidal action of hypocrellin A (HA), a PQ derivative, we showed that yeast cells escaped killing by trapping toxins inside LDs. Furthermore, LD-deficient mutants were hypersusceptible to HA-mediated phototoxins and other fungicides. Our study identified a previously unrecognised function of LDs in fungi that has implications for our understanding of environmental adaptation strategies for fungi and antifungal drug discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.