Evidence map›Paper›PMID 26463545›Full record

ArticleSocial science research2015

Life events, genetic susceptibility, and smoking among adolescents.

Fred C Pampel, Jason D Boardman, Jonathan Daw, Michael C Stallings, Andrew Smolen, Brett C Haberstick, Keith F Widaman, Tricia K Neppl, Rand D Conger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social science research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. DRD4 interacts with adverse life events in predicting maternal sensitivity via emotion regulation.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2018
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fred C PampelInstitute of Behavioral Science, University of Colorado Boulder, United States. Electronic address: fred.pampel@colorado.edu.
Jason D BoardmanInstitute of Behavioral Science, University of Colorado Boulder, United States.
Jonathan DawDepartment of Sociology, Pennsylvania State University, United States.
Michael C StallingsInstitute for Behavioral Genetics, University of Colorado Boulder, United States.
Andrew SmolenInstitute for Behavioral Genetics, University of Colorado Boulder, United States.
Brett C HaberstickInstitute for Behavioral Genetics, University of Colorado Boulder, United States.
Keith F WidamanDepartment of Psychology, University of California Davis, United States.
Tricia K NepplDepartment of Human Development and Family Studies, Iowa State University, United States.
Rand D CongerDepartment of Human Ecology, University of California Davis, United States.

Funding

A Genetic Study of Personal Traits that Promote or Inhibit Individual Well-BeingR01HD064687 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CONGER, RAND DONALD, DONNELLAN, MICHAEL BRENT · 2010 to 2014
$4.3M
University of Colorado Population CenterP2CHD066613 · NICHD · UNIVERSITY OF COLORADO · PI JANE A MENKEN · 2015 to 2026
$3.7M
The University of Colorado Population CenterR24HD066613 · NICHD · UNIVERSITY OF COLORADO · PI PAMPEL, FRED C · 2010 to 2014
$1.9M
NICHD NIH HHS P2C HD066613NICHD NIH HHS R01 HD064687NICHD NIH HHS R24 HD066613
6 · The paper itself

Abstract

Although stressful life events during adolescence are associated with the adoption of unhealthy behaviors such as smoking, both social circumstances and physical traits can moderate the relationship. This study builds on the stress paradigm and gene-environment approach to social behavior by examining how a polymorphism in the serotonin transporter gene 5-HTTLPR moderates the effect of life events on adolescent smoking. Tests of interaction hypotheses use data from the Family Transitions Project, a longitudinal study of 7th graders followed for 5years. A sibling-pair design with separate models for the gender composition of pairs (brothers, sisters, or brother/sister) controls for unmeasured family background. The results show that negative life events are significantly and positively associated with smoking. Among brother pairs but not other pairs, the results provide evidence of gene-environment interaction by showing that life events more strongly influence smoking behavior for those with more copies of the 5-HTTLPR S allele.

Indexed as

Adolescent BehaviorEpigenesis, GeneticGenotypeSmokingStress, PsychologicalAdolescentAllelesEnvironmentFemaleGenetic Predisposition to DiseaseHealth BehaviorHumansLongitudinal StudiesMalePolymorphism, GeneticSerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human5-HTTLPRAdolescent smokingGene–environment interactionNegative life eventsStress

Identifiers

PMID26463545
PMCPMC4607932

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.