SynthesisInflammation2016
No Association Between -159C/T Polymorphism of the CD14 Gene and Asthma Risk: a Meta-Analysis of 36 Case-Control Studies.
Synthesis in Inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The CD14 (-159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have evaluated the association between -159C/T polymorphism of the CD14 gene and asthma risk; however, these studies have yielded inconsistent results. We performed meta-analyses to investigate the association between CD14-159C/T polymorphism and asthma risk. Studies were identified from PubMed, Embase, and two Chinese databases. Odds ratios (ORs) with 95 % confidence interval (CI) were used to evaluate the strength of association. Thirty-six studies were collected for meta-analysis, which involved 6954 cases and 7525 controls. In the overall populations, no significant association between the CD14-159C/T polymorphism and asthma risk was found for the dominant (OR = 0.90, 95 % CI = 0.81-1.01, P = 0.08) or other models; stratified analyses indicated that the CD14-159C/T polymorphism was not associated with asthma risk in Caucasians or Asians or adults or children. Among the atopic asthma populations, no significant results were observed in the all-combined or subgroup analyses. This meta-analysis demonstrates that the CD14-159C/T polymorphism may not be a risk factor for asthma.
Indexed as
Identifiers
26463530What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.