ArticleBMJ open2015
Association between low dietary zinc and hyperuricaemia in middle-aged and older males in China: a cross-sectional study.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Estimation of Hair Toxic and Essential Trace Element and Mineral Profiles of Patients with Chronic Gout.Biological trace element research · 2025Article
- A cross-sectional study of the association between blood metal mixtures exposure and hyperuricemia.Clinical rheumatology · 2024Article
- Association Between Circulating Zinc Levels and Risk Factors of Metabolic Syndrome: Insights from a Bi-directional Mendelian Randomization Analysis and Cross-Sectional Study.Biological trace element research · 2024Article
- Association between dietary selenium intake and the prevalence of osteoporosis and its role in the treatment of glucocorticoid-induced osteoporosis.Journal of orthopaedic surgery and research · 2023Article
- Joint Effect of Multiple Metals on Hyperuricemia and Their Interaction with Obesity: A Community-Based Cross-Sectional Study in China.Nutrients · 2023Article
- Associations between blood essential metal mixture and serum uric acid: a cross-sectional study.Frontiers in public health · 2023Article
- The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China.Frontiers in public health · 2023Article
- Composite Dietary Antioxidant Index Is Negatively Associated with Hyperuricemia in US Adults: An Analysis of NHANES 2007-2018.International journal of endocrinology · 2023Article
- Association of dietary patterns with blood uric acid concentration and hyperuricemia in northern Chinese adults.Nutrition journal · 2022Article
- Recent advances in the application of ionomics in metabolic diseases.Frontiers in nutrition · 2022Review
- Ameliorative effect and mechanism of Yi-Suan-Cha against hyperuricemia in rats.Journal of clinical laboratory analysis · 2021Article
- Combined effects of dietary zinc at 3 years of age and obesity at 7 years of age on the serum uric acid levels of Korean children.Nutrition research and practice · 2020Article
- Association between serum copper levels and prevalence of hyperuricemia: a cross-sectional study.Scientific reports · 2020Article
- Association between pre-and postnatal growth and longitudinal trends in serum uric acid levels and blood pressure in children aged 3 to 7 years.BMC pediatrics · 2020Article
- Association between dietary selenium intake and the prevalence of osteoporosis: a cross-sectional study.BMC musculoskeletal disorders · 2019Article
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- Factors Attenuating Zinc Deficiency Improvement in Direct-Acting Antiviral Agent-Treated Chronic Hepatitis C Virus Infection.Nutrients · 2018Article
- Article
- Association between Dietary Zinc Intake and Hyperuricemia among Adults in the United States.Nutrients · 2018Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the associations between dietary zinc intake and hyperuricaemia.
designCross-sectional study.
settingThis study was conducted in a health examination centre of China.
participantsA total of 5168 middle-aged and older participants (aged 40 years or above) (2697 men and 2471 women) were included. OUTCOME MEASURES: Dietary zinc intake was assessed using a validated semiquantitative food frequency questionnaire. Hyperuricaemia was defined as uric acid ≥416 µmol/L for males and ≥360 µmol/L for females.
resultsFor males, the prevalence of hyperuricaemia was 22.9%. After adjusting for age, body mass index (BMI) and energy intake, the ORs were 0.68 (95% CI 0.45 to 0.92) in the second quintile, 0.63 (95% CI 0.45 to 0.89) in the third quintile, 0.68 (95% CI 0.46 to 1.00) in the fourth quintile and 0.55 (95% CI 0.35 to 0.87) in the fifth quintile comparing the lowest quintile of Zn intake, respectively (p for trend=0.03). In the multivariable adjusted model, the relative odds of hyperuricaemia were significantly decreased by 0.71 times in the second quintile of zinc intake (OR 0.71, 95% CI 0.52 to 0.98), 0.64 times in the third quintile (OR 0.65, 95% CI 0.44 to 0.94) and 0.55 times in the fifth quintile (OR 0.56, 95% CI 0.32 to 0.97) compared with those in the lowest quintile, and p for trend was 0.064. For females, the prevalence of hyperuricaemia was 10.0%, and unadjusted, minimally adjusted as well as multivariable adjusted ORs all suggested no significant association between dietary zinc intake and hyperuricaemia.
conclusionsThe findings of this cross-sectional study indicated that dietary zinc intake was inversely associated with hyperuricaemia in middle-aged and older males, but not in females. The association was significant after considering the influence of age, BMI and energy intake, and after that, minimum adjustment remained independent of further confounding factors such as vitamin C intake, alcohol drinking status and nutrient supplementation.
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