ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2016
Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 4 of them syntheses that pooled it.
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Who cites it
81 citing papers in PubMed, 4 syntheses or guidelines pooled it, 193 citations in OpenAlex.
- Is the Juice Worth the Squeeze? Vitamin C Supplementation in Hemodialysis Patients: A Systematic Review.Nutrients · 2026Pooled it
- Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis.Urolithiasis · 2020Pooled it
- Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement.Journal of nephrology · 2016Guideline
- Brazilian Guidelines on evaluation and clinical management of Nephrolithiasis: Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- Potassium Citrate is Better in Reducing Salt and Increasing Urine pH than Oral Intake of Lemonade: A Cross-Over Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Trial
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- Urolithiasis in patients with cancer.Nature reviews. Urology · 2026Review
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- Beyond expensive innovations: affordable and effective strategies for managing tubulopathies in adults.Clinical kidney journal · 2026Review
- Between Deficiency and Excess: The Dual Role of Selected Dietary Supplements in Immune Health.Cureus · 2026Review
- Exploration of the association of antidiabetic drugs with urolithiasis: A drug-targeted Mendelian randomization study.Asian journal of urology · 2026Article
- Individual and joint associations of modifiable metabolic status and lifestyle with kidney stones among sedentary population: insights from a nationally representative dataset.International journal of surgery (London, England) · 2026Article
- Scoping review of micronutrient imbalances, clinical manifestations, and interventions.World journal of methodology · 2025Review
- Market analysis of vitamin C-containing dietary supplements in Germany and the USA: Consumer information and risks and benefits.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Serum Vitamin C concentrations are inversely related to biological aging: a population-based cross-sectional study.European journal of medical research · 2025Article
- Review
- A case report of renal oxalosis and secondary hyperoxaluria due to chronic high vitamin C consumption.Clinical nephrology. Case studies · 2025Article
- Associations between comprehensive dietary composition and kidney stone risk: insights from a nationally representative survey.Frontiers in nutrition · 2025Article
- Dietary Guidelines Post Kidney Transplant: Is This the Missing Link in Recovery and Graft Survival?Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
21 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies of vitamin C and kidney stones were conducted mostly in men and either reported disparate results for supplemental and dietary vitamin C or did not examine dietary vitamin C. STUDY
designProspective cohort analysis. SETTING &
participants156,735 women in the Nurses' Health Study (NHS) I and II and 40,536 men in the Health Professionals Follow-up Study (HPFS). PREDICTOR: Total, dietary, and supplemental vitamin C intake, adjusted for age, body mass index, thiazide use, and dietary factors. OUTCOMES: Incident kidney stones.
resultsDuring a median follow-up of 11.3 to 11.7 years, 6,245 incident kidney stones were identified. After multivariable adjustment, total vitamin C intake (<90 [reference], 90-249, 250-499, 500-999, and ≥1,000mg/d) was not significantly associated with risk for kidney stones among women, but was among men (HRs of 1.00 [reference], 1.19 [95% CI, 0.99-1.46], 1.15 [95% CI, 0.93-1.42], 1.29 [95% CI, 1.04-1.60], and 1.43 [95% CI, 1.15-1.79], respectively; P for trend = 0.005). Median total vitamin C intake for the 500- to 999-mg/d category was ∼700mg/d. Supplemental vitamin C intake (no use [reference], <500, 500-999, and ≥1,000mg/d) was not significantly associated with risk for kidney stones among women, but was among men (HR, 1.19 [95% CI, 1.01-1.40] for ≥1,000mg/d; P for trend = 0.001). Dietary vitamin C intake was not associated with stones among men or women, although few participants had dietary intakes > 700mg/d. LIMITATIONS: Nutrient intakes derived from food-frequency questionnaires, lack of data on stone composition for all cases.
conclusionsTotal and supplemental vitamin C intake was significantly associated with higher risk for incident kidney stones in men, but not in women.
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