ArticlePlant physiology2015
Glutathione Regulates 1-Aminocyclopropane-1-Carboxylate Synthase Transcription via WRKY33 and 1-Aminocyclopropane-1-Carboxylate Oxidase by Modulating Messenger RNA Stability to Induce Ethylene Synthesis during Stress.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed, 107 citations in OpenAlex.
- CaEMBO reports · 2025Article
- Genome-Wide Identification and Expression Analysis of 1-Aminocyclopropane-1-Carboxylate Synthase (ACS) Gene Family inInternational journal of molecular sciences · 2025Article
- Glutathione Involvement in Potato Response to French Marigold Volatile Organic Compounds.Antioxidants (Basel, Switzerland) · 2024Article
- Genome-Wide In Silico Analysis of 1-Aminocyclopropane-1-carboxylate oxidase (ACO) Gene Family in Rice (Plants (Basel, Switzerland) · 2024Article
- The role of ethylene in the regulation of plant response mechanisms to waterlogging stress.Plant cell reports · 2024Review
- Sulfate Availability and Hormonal Signaling in the Coordination of Plant Growth and Development.International journal of molecular sciences · 2024Review
- The Ethylene Biosynthetic Enzymes, 1-Aminocyclopropane-1-Carboxylate (ACC) Synthase (ACS) and ACC Oxidase (ACO): The Less Explored Players in Abiotic Stress Tolerance.Biomolecules · 2024Review
- Article
- Transcriptomic Analysis Reveals the Response Mechanisms of Bell Pepper (Metabolites · 2023Article
- NO Is Not the Same as GSNO in the Regulation of Fe Deficiency Responses by Dicot Plants.International journal of molecular sciences · 2023Review
- The NAC transcription factors SNAP1/2/3/4 are central regulators mediating high nitrogen responses in mature nodules of soybean.Nature communications · 2023Article
- A role for ethylene signaling and biosynthesis in regulating and accelerating COThe New phytologist · 2023Article
- Transcriptome and Low-Affinity Sodium Transport Analysis Reveals Salt Tolerance Variations between Two Poplar Trees.International journal of molecular sciences · 2023Article
- Genome scale analysis of 1-aminocyclopropane-1-carboxylate oxidase gene family in G. barbadense and its functions in cotton fiber development.Scientific reports · 2023Article
- Antioxidant Potential of Glutathione and Crosstalk with Phytohormones in Enhancing Abiotic Stress Tolerance in Crop Plants.Plants (Basel, Switzerland) · 2023Review
- CdWRKY2 transcription factor modulates salt oversensitivity in bermudagrass [Frontiers in plant science · 2023Article
- Glutathione imparts stress tolerance againstPlant signaling & behavior · 2022Article
- Review
- Comparative Transcriptome and Co-Expression Network Analyses Reveal the Molecular Mechanism of Calcium-Deficiency-Triggered Tipburn in Chinese Cabbage (Plants (Basel, Switzerland) · 2022Article
- Thiol-based Oxidative Posttranslational Modifications (OxiPTMs) of Plant Proteins.Plant & cell physiology · 2022Review
5 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione (GSH) plays a fundamental role in plant defense-signaling network. Recently, we have established the involvement of GSH with ethylene (ET) to combat environmental stress. However, the mechanism of GSH-ET interplay still remains unexplored. Here, we demonstrate that GSH induces ET biosynthesis by modulating the transcriptional and posttranscriptional regulations of its key enzymes, 1-aminocyclopropane-1-carboxylate synthase (ACS) and 1-aminocyclopropane-1-carboxylate oxidase (ACO). Transgenic Arabidopsis (Arabidopsis thaliana) plants with enhanced GSH content (AtECS) exhibited remarkable up-regulation of ACS2, ACS6, and ACO1 at transcript as well as protein levels, while they were down-regulated in the GSH-depleted phytoalexin deficient2-1 (pad2-1) mutant. We further observed that GSH induced ACS2 and ACS6 transcription in a WRKY33-dependent manner, while ACO1 transcription remained unaffected. On the other hand, the messenger RNA stability for ACO1 was found to be increased by GSH, which explains our above observations. In addition, we also identified the ACO1 protein to be a subject for S-glutathionylation, which is consistent with our in silico data. However, S-glutathionylation of ACS2 and ACS6 proteins was not detected. Further, the AtECS plants exhibited resistance to necrotrophic infection and salt stress, while the pad2-1 mutant was sensitive. Exogenously applied GSH could improve stress tolerance in wild-type plants but not in the ET-signaling mutant ethylene insensitive2-1, indicating that GSH-mediated resistance to these stresses occurs via an ET-mediated pathway. Together, our investigation reveals a dual-level regulation of ET biosynthesis by GSH during stress.
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