ArticleScientific reports2015
How astrocyte networks may contribute to cerebral metabolite clearance.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 102 citations in OpenAlex.
- Advection and diffusion in perivascular and extracellular spaces in the brain.Journal of the Royal Society, Interface · 2025Article
- Simulating the impact of tumor mechanical forces on glymphatic networks in the brain parenchyma.Biomechanics and modeling in mechanobiology · 2024Article
- A brain-wide solute transport model of the glymphatic system.Journal of the Royal Society, Interface · 2024Article
- Hydraulic resistance of three-dimensional pial perivascular spaces in the brain.Fluids and barriers of the CNS · 2024Article
- Astrocyte regulation of extracellular space parameters across the sleep-wake cycle.Frontiers in cellular neuroscience · 2024Review
- Effects of sleep on brain perivascular space in a cognitively healthy population.Sleep medicine · 2023Article
- Hydraulic resistance of three-dimensional pial perivascular spaces in the brain.Research square · 2023Article
- Sizes and shapes of perivascular spaces surrounding murine pial arteries.Fluids and barriers of the CNS · 2023Article
- Neural activity induces strongly coupled electro-chemo-mechanical interactions and fluid flow in astrocyte networks and extracellular space-A computational study.PLoS computational biology · 2023Article
- Review
- Quantification of blood-brain barrier water exchange and permeability with multidelay diffusion-weighted pseudo-continuous arterial spin labeling.Magnetic resonance in medicine · 2023Article
- Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath.Fluids and barriers of the CNS · 2023Article
- Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries.Research square · 2023Article
- Regulation of Physiological Barrier Function by the Commensal Microbiota.Life (Basel, Switzerland) · 2023Review
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- Transport in the Brain Extracellular Space: Diffusion, but Which Kind?International journal of molecular sciences · 2022Review
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Blood-brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders.Molecular brain · 2022Review
- Sensitivity analysis on a network model of glymphatic flow.Journal of the Royal Society, Interface · 2022Article
- A network model of glymphatic flow under different experimentally-motivated parametric scenarios.iScience · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain possesses an intricate network of interconnected fluid pathways that are vital to the maintenance of its homeostasis. With diffusion being the main mode of solute transport in cerebral tissue, it is not clear how bulk flow through these pathways is involved in the removal of metabolites. In this computational study, we show that networks of astrocytes may contribute to the passage of solutes between tissue and paravascular spaces (PVS) by serving as low resistance pathways to bulk water flow. The astrocyte networks are connected through aquaporin-4 (AQP4) water channels with a parallel, extracellular route carrying metabolites. Inhibition of the intracellular route by deletion of AQP4 causes a reduction of bulk flow between tissue and PVS, leading to reduced metabolite clearance into the venous PVS or, as observed in animal studies, a reduction of tracer influx from arterial PVS into the brain tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.