ReviewAgeing research reviews2015
Successful aging: Advancing the science of physical independence in older adults.
2 registry-linked trialsAbstract readReview
In one paragraph
Review in Ageing research reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 132 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement (FASTING ENHANCE)
Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
Who cites it
132 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association between dietary diversity and healthy aging: a systematic review.BMC nutrition · 2025Pooled it
- Recognition of Bathroom Activities in Older Adults Using Wearable Sensors: A Systematic Review and Recommendations.Sensors (Basel, Switzerland) · 2021Pooled it
- What are the most effective interventions to improve physical performance in pre-frail and frail adults? A systematic review of randomised control trials.BMC geriatrics · 2019Pooled it
- The reliability and validity of ultrasound to quantify muscles in older adults: a systematic review.Journal of cachexia, sarcopenia and muscle · 2017Pooled it
- Comparing the Effectiveness of High Intensity Interval Training vs Continuous Moderate Intensity Exercise on Physical Function Among Older Adults With HIV.Open forum infectious diseases · 2026Trial
- The Effects of Eye Exercises on Eye-Hand Coordination, Cognitive Functions and Balance Ability of the Elderly: A Randomized Controlled Trial.International journal of environmental research and public health · 2025Trial
- The Effectiveness of an App-Based Fitness Program on Self-Perceived Physical Functioning in Older Adults: Randomized Waitlist-Controlled Trial.Journal of medical Internet research · 2025Trial
- Geographical Differences in the Self-Reported Functional Impairment of People With Human Immunodeficiency Virus (HIV) and Associations With Cardiometabolic Risk.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022 · on this mapTrial
- Depressive symptoms exacerbate disability in older adults: A prospective cohort analysis of participants in the MemAID trial.PloS one · 2022Trial
- Trial
- Disability Prevention Program Improves Life-Space and Falls Efficacy: A Randomized Controlled Trial.Journal of the American Geriatrics Society · 2021Trial
- Trial
- Frailty and COPD: a bidirectional relationship in the context of systemic and accelerated ageing.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study.BMC medicine · 2026Article
- Reference values for gait speed, five-times-sit-to-stand test, balance, and handgrip strength: analysis of data from the English Longitudinal Study of Ageing.GeroScience · 2026Article
- Bridging patient-reported outcomes and performance assessments in older adults: linking the Short Physical Performance Battery to the standardised PROMIS Physical Function scale.Age and ageing · 2026Article
- Engaging Older Adults to Guide the Development of Passive Home Health Monitoring to Support Aging in Place.Sensors (Basel, Switzerland) · 2025Article
- Review
- Sarcopenia and sleep duration with the likelihood of successful aging among older adults in China: a prospective cohort study.BMC geriatrics · 2025Article
- Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Stephen D AntonUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: santon@ufl.edu.
Adam J WoodsUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States; University of Florida, Cognitive Aging & Memory Clinical Translational Research Program, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: ajwoods@ufl.edu.
Tetso AshizawaUniversity of Florida, Department of Neurology, 100 Newell Drive, Gainesville, FL 32610, United States. Electronic address: tetsuo.ashizawa@neurology.ufl.edu.
Diana BarbUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States; University of Florida, Department of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, United States. Electronic address: diana.barb@medicine.ufl.edu.
Thomas W BufordUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: tbuford@ufl.edu.
Christy S CarterUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: cartercs@ufl.edu.
David J ClarkUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: davidclark@ufl.edu.
Ronald A CohenUniversity of Florida, Cognitive Aging & Memory Clinical Translational Research Program, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: roncohen@ufl.edu.
Duane B CorbettUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: dcorbett@ufl.edu.
Yenisel Cruz-AlmeidaUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States; University of Florida, Cognitive Aging & Memory Clinical Translational Research Program, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: cryeni@ufl.edu.
Vonetta DotsonUniversity of Florida, Cognitive Aging & Memory Clinical Translational Research Program, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: vonetta@ufl.edu.
Natalie EbnerUniversity of Florida, Department of Psychology, 945 Center Drive, P.O. Box 112250, Gainesville, FL 32611, United States. Electronic address: natalie.ebner@ufl.edu.
Philip A EfronUniversity of Florida, Department of Surgery, P.O. Box 100286, Gainesville, FL 32610, United States. Electronic address: Philip.efron@surgery.ufl.edu.
Roger B FillingimUniversity of Florida, Department of Community Dentistry and Behavioral Science, 1329 SW Archer Road, Gainesville, FL 32610, United States. Electronic address: RFillingim@ufl.edu.
Thomas C FosterUniversity of Florida, Cognitive Aging & Memory Clinical Translational Research Program, 2004 Mowry Road, Gainesville, FL 32611, United States; University of Florida, Department of Neuroscience, P.O. Box 100244, Gainesville, FL 32610, United States. Electronic address: foster1@ufl.edu.
David M GundermannUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: dgunderm@ufl.edu.
Anna-Maria JosephUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: amjoseph@ufl.edu.
Christy KarabetianUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States; University of Florida, Department of Clinical & Health Psychology, 1225 Center Drive, Gainesville, FL 32610, United States. Electronic address: ckarabetian@phhp.ufl.edu.
Christiaan LeeuwenburghUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: cleeuwen@ufl.edu.
Todd M ManiniUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: tmanini@ufl.edu.
Michael MarsiskeUniversity of Florida, Department of Clinical & Health Psychology, 1225 Center Drive, Gainesville, FL 32610, United States. Electronic address: marsiske@phhp.ufl.edu.
Robert T MankowskiUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: r.mankowski@ufl.edu.
Heather L MutchieUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: hmutchie@ufl.edu.
Michael G PerriUniversity of Florida, Department of Clinical & Health Psychology, 1225 Center Drive, Gainesville, FL 32610, United States. Electronic address: mperri@phhp.ufl.edu.
Sanjay RankaUniversity of Florida, Department of Computer & Information Science & Engineering, P.O. Box 116120, Gainesville, FL 32611, United States. Electronic address: ranka@cise.ufl.edu.
Parisa RashidiUniversity of Florida, Department of Biomedical Engineering, P.O. Box 116131, Gainesville, FL 32610, United States. Electronic address: parisa.rashidi@bme.ufl.edu.
Bhanuprasad SandesaraUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: bsandesara@ufl.edu.
Philip J ScarpaceUniversity of Florida, Department of Pharmacology & Therapeutics, P.O. Box 100267, Gainesville, FL 32610, United States. Electronic address: scarpace@ufl.edu.
Kimberly T SibilleUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: ksibille@ufl.edu.
Laurence M SolbergUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: lmsolberg@ufl.edu.
Shinichi SomeyaUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: someya@ufl.edu.
Connie UpholdUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: upholdc@ufl.edu.
Stephanie WohlgemuthUniversity of Florida, Department of Animal Sciences, 2250 Shealy Drive, Gainesville, FL 32611, United States. Electronic address: steffiw@ufl.edu.
Samuel Shangwu WuUniversity of Florida, Department of Biostatistics, P.O. Box 117450, Gainesville, FL 32611, United States. Electronic address: samwu@biostat.ufl.edu.
Marco PahorUniversity of Florida, Department of Aging and Geriatric Research, 2004 Mowry Road, Gainesville, FL 32611, United States. Electronic address: mpahor@ufl.edu.
Funding
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MWake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4MUniversity of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8MInstitute on Aging Clinical Translational Research BuildingC06RR029852 · NCRR · UNIVERSITY OF FLORIDA · PI PAHOR, MARCO · 2010 to 2010
$14.7MUF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2MTogether: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5MCochlear Detoxification SystemR01DC014437 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2015 to 2019
$2.2MMitochondrial Thioredoxin, Caloric Restriction, and Age-related Hearing LossR01DC012552 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2013 to 2017
$1.9MUF Clinical and Translational Science AwardKL2TR000065 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$1.6MMetabolic Costs of Daily Activities in Older AdultsR01AG042525 · NIA · UNIVERSITY OF FLORIDA · PI MANINI, TODD · 2013 to 2017
$1.6MHematopoietic Stem Cell Dysfunction in the Elderly after Severe InjuryR01GM113945 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2015 to 2019
$1.6MMtDNA variant modifiers of cardiopulmonary responsiveness to physical activityR01HL121023 · NHLBI · UNIVERSITY OF FLORIDA · PI FRAGOSO, CARLOS A. VAZ, MANINI, TODD · 2014 to 2017
$1.3MNCATS NIH HHS KL2 TR000065NCATS NIH HHS KL2 TR001429NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1TR000064NCATS NIH HHS UL1 TR001427NCRR NIH HHS C06 RR029852NHLBI NIH HHS R01 HL121023NIA NIH HHS K01 AG048259NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG028740NIA NIH HHS P30AG028740NIA NIH HHS R01 AG042525NIDCD NIH HHS R01 DC012552NIDCD NIH HHS R01 DC014437NIDCD NIH HHS R03 DC011840NIGMS NIH HHS R01 GM113945
Abstract
The concept of 'successful aging' has long intrigued the scientific community. Despite this long-standing interest, a consensus definition has proven to be a difficult task, due to the inherent challenge involved in defining such a complex, multi-dimensional phenomenon. The lack of a clear set of defining characteristics for the construct of successful aging has made comparison of findings across studies difficult and has limited advances in aging research. A consensus on markers of successful aging is furthest developed is the domain of physical functioning. For example, walking speed appears to be an excellent surrogate marker of overall health and predicts the maintenance of physical independence, a cornerstone of successful aging. The purpose of the present article is to provide an overview and discussion of specific health conditions, behavioral factors, and biological mechanisms that mark declining mobility and physical function and promising interventions to counter these effects. With life expectancy continuing to increase in the United States and developed countries throughout the world, there is an increasing public health focus on the maintenance of physical independence among all older adults.
Indexed as
AgingExerciseActivities of Daily LivingAdultHealth BehaviorHumansPhysical Conditioning, HumanAgeHealthspanLongevityMobilityObesitySarcopenia
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT05732935ClinicalTrials.gov
NCT07180147ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.