ReviewDigestive diseases and sciences2016
Current Concepts in Diabetes Mellitus and Chronic Liver Disease: Clinical Outcomes, Hepatitis C Virus Association, and Therapy.
Review in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Hepatitis C virus infection and development of type 2 diabetes mellitus: Systematic review and meta-analysis of the literature.Reviews in endocrine & metabolic disorders · 2018Pooled it
- From cirrhosis to hepatogenous diabetes: risk factors and glycemic management.Archives of medical science : AMS · 2025Article
- Associations between type 2 diabetes mellitus and chronic liver diseases: evidence from a Mendelian randomization study in Europeans and East Asians.Frontiers in endocrinology · 2024Article
- Outpatient albumin infusions reduce hospitalizations and improve outcomes in decompensated cirrhosis: A real-world cohort study.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Understanding Insulin in the Age of Precision Medicine and Big Data: Under-Explored Nature of Genomics.Biomolecules · 2023Review
- Clinical implications of diabetes in chronic liver disease: Diagnosis, outcomes and management, current and future perspectives.World journal of gastroenterology · 2022Review
- Metabolic Disorders in Patients with Chronic Hepatitis B Virus Infection: Coffee as a Panacea? (ANRS CO22 Hepather Cohort).Antioxidants (Basel, Switzerland) · 2022Article
- Association of Type 2 Diabetes and Hepatic Encephalopathy in Chronic Liver Disease Patients.Cureus · 2021Article
- Chronic Viral Hepatitis in a Cohort of Inflammatory Bowel Disease Patients from Southern Italy: A Case-Control Study.Pathogens (Basel, Switzerland) · 2020Article
- Association between hepatitis C antiviral treatment and diabetes mellitus: A case series.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2020Article
- Article
- The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment.Molecules (Basel, Switzerland) · 2020Article
- Management of Diabetes Mellitus in Patients with Chronic Liver Diseases.Journal of diabetes research · 2019Review
- The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment.Medicine · 2018Article
- No Improvement in Hemoglobin A1c Following Hepatitis C Viral Clearance in Patients With and Without HIV.The Journal of infectious diseases · 2017Article
- A preliminary analysis of hepatitis C virus in pancreatic islet cells.Virology journal · 2017Article
- Diagnosis and Treatment of Chronic Hepatitis C with Concomitant Extrahepatic Manifestations Deserves a Closer Look.Journal of translational internal medicine · 2017Article
- Diabetes Mellitus is Associated With Higher Risk of Developing Decompensated Cirrhosis in Chronic Hepatitis C Patients.Journal of clinical gastroenterology · 2017Article
- A Different Perspective for Management of Diabetes Mellitus: Controlling Viral Liver Diseases.Journal of diabetes research · 2017Review
- Retrospective study of the associations between hepatitis C virus infection and metabolic factors.World journal of hepatology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hereditary type 2 diabetes mellitus is a risk factor for chronic liver disease, and ~30 % of patients with liver cirrhosis develop diabetes. Diabetes mellitus has been associated with cirrhotic and non-cirrhotic hepatitis C virus liver infection, can aggravate the course the liver infection, and can induce a lower sustained response to antiviral treatment. Evidences that HCV may induce metabolic and autoimmune disturbances leading to hypobetalipoproteinemia, steatosis, insulin resistance, impaired glucose tolerance, thyroid disease, and gonadal dysfunction have been found. Prospective studies have demonstrated that diabetes increases the risk of liver complications and death in patients with cirrhosis. However, treatment of diabetes in these patients is complex, as antidiabetic drugs can promote hypoglycemia and lactic acidosis. There have been few therapeutic studies evaluating antidiabetic treatments in patients with liver cirrhosis published to date; thus, the optimal treatment for diabetes and the impact of treatment on morbidity and mortality are not clearly known. As numbers of patients with chronic liver disease and diabetes mellitus are increasing, largely because of the global epidemics of obesity and nonalcoholic fatty liver disease, evaluation of treatment options is becoming more important. This review discusses new concepts on hepatogenous diabetes, the diabetes mellitus–hepatitis C virus association, and clinical implications of diabetes mellitus in patients with chronic liver disease. In addition, the effectiveness and safety of old and new antidiabetic drugs, including incretin-based therapies, will be described.
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