ArticleJournal of the American Chemical Society2015
Amplifying the sensitivity of zinc(II) responsive MRI contrast agents by altering water exchange rates.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed.
- Molecular Imaging of In Vivo Zinc Distribution Using Nuclear and Magnetic Resonance Imaging.Chemical & biomedical imaging · 2026Review
- Microenvironment-responsive size-adaptive nanoparticles: hyaluronidase/acid/NIR light activation for deep-penetration trimodal therapy.Materials today. Bio · 2025Article
- Molecular MRI of Dysregulated Zinc Secretion Detects Pancreatic Ductal Adenocarcinoma and Response to KRASG12D Inhibitor Treatment.Cancer research · 2025Article
- Zn(II)-Responsive MRI Probe Based on an Fe(III) Macrocyclic Complex.Inorganic chemistry · 2024Article
- The role of responsive MRI probes in the past and the future of molecular imaging.Chemical science · 2024Review
- Impact of dietary zinc on stimulated zinc secretion MRI in the healthy and malignant mouse prostate.Npj imaging · 2024Article
- Imaging zinc trafficking in vivo by positron emission tomography with zinc-62.Metallomics : integrated biometal science · 2022Article
- Non-invasive radionuclide imaging of trace metal trafficking in health and disease: "PET metallomics".RSC chemical biology · 2022Review
- Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders.Science advances · 2021Article
- Paramagnetic MnACS applied materials & interfaces · 2021Article
- Fast Ion-Chelate Dissociation Rate forJournal of the American Chemical Society · 2021Article
- Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions.Angewandte Chemie (International ed. in English) · 2021Article
- Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.Inorganic chemistry · 2021Article
- Imaging Beta-Cell Function in the Pancreas of Non-Human Primates Using a Zinc-Sensitive MRI Contrast Agent.Frontiers in endocrinology · 2021Article
- Imaging β-Cell Function Using a Zinc-Responsive MRI Contrast Agent May Identify First Responder Islets.Frontiers in endocrinology · 2021Article
- From Zn(II) to Cu(II) Detection by MRI Using Metal-Based Probes: Current Progress and Challenges.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Comparison of the equilibrium, kinetic and water exchange properties of some metal ion-DOTA and DOTA-bis(amide) complexes.Journal of inorganic biochemistry · 2020Article
- Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.Dalton transactions (Cambridge, England : 2003) · 2020Article
- HyperpolarizedCommunications chemistry · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Given the known water exchange rate limitations of a previously reported Zn(II)-sensitive MRI contrast agent, GdDOTA-diBPEN, new structural targets were rationally designed to increase the rate of water exchange to improve MRI detection sensitivity. These new sensors exhibit fine-tuned water exchange properties and, depending on the individual structure, demonstrate significantly improved longitudinal relaxivities (r1). Two sensors in particular demonstrate optimized parameters and, therefore, show exceptionally high longitudinal relaxivities of about 50 mM(-1) s(-1) upon binding to Zn(II) and human serum albumin (HSA). This value demonstrates a 3-fold increase in r1 compared to that displayed by the original sensor, GdDOTA-diBPEN. In addition, this study provides important insights into the interplay between structural modifications, water exchange rate, and kinetic stability properties of the sensors. The new high relaxivity agents were used to successfully image Zn(II) release from the mouse pancreas in vivo during glucose stimulated insulin secretion.
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