ReviewBiochemistry insights2015
Extracellular Matrix and Integrins in Embryonic Stem Cell Differentiation.
Review in Biochemistry insights, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- The Synthetic Extracellular Matrix as a Maestro of the In Vitro Stem Cell Niche: Orchestrating Fate and Function.Biomedicines · 2026Review
- Synthetic thermoresponsive scaffolds for the expansion and differentiation of human pluripotent stem cells into cardiomyocytes.RSC advances · 2025Article
- Embryoid bodies as a model system for exploring early human embryonic development.Journal of assisted reproduction and genetics · 2025Review
- Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel.Development (Cambridge, England) · 2024Article
- DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells.RNA (New York, N.Y.) · 2022Article
- Ligand functionalization of titanium nanopattern enables the analysis of cell-ligand interactions by super-resolution microscopy.Nature protocols · 2022Review
- Application of Bio-Active Elastin-like Polypeptide on Regulation of Human Mesenchymal Stem Cell Behavior.Biomedicines · 2022Article
- Generation, Transmission, and Regulation of Mechanical Forces in Embryonic Morphogenesis.Small (Weinheim an der Bergstrasse, Germany) · 2022Review
- Kinases of the Focal Adhesion Complex Contribute to Cardiomyocyte Specification.International journal of molecular sciences · 2021Article
- Mechanisms of Endothelial-to-Mesenchymal Transition Induction by Extracellular Matrix Components in Pulmonary Fibrosis.Bulletin of experimental biology and medicine · 2021Article
- Layer-Number-Dependent Effects of Graphene Oxide on the Pluripotency of Mouse Embryonic Stem Cells Through the Regulation of the Interaction Between the Extracellular Matrix and Integrins.International journal of nanomedicine · 2021Article
- Generation of GABAergic striatal neurons by a novel iPSC differentiation protocol enabling scalability and cryopreservation of progenitor cells.Cytotechnology · 2020Article
- p75NTR optimizes the osteogenic potential of human periodontal ligament stem cells by up-regulating α1 integrin expression.Journal of cellular and molecular medicine · 2020Article
- Biomimetic hydrogels with spatial- and temporal-controlled chemical cues for tissue engineering.Biomaterials science · 2020Review
- Peptide nucleic acid based tension sensor for cellular force imaging with strong DNase resistance.Biosensors & bioelectronics · 2020Article
- Integrin alpha-5 subunit is critical for the early stages of human pluripotent stem cell cardiac differentiation.Scientific reports · 2019Article
- Review
- mRNA and miRNA expression profiles in an ectoderm-biased substate of human pluripotent stem cells.Scientific reports · 2019Article
- Quantified forces between HepG2 hepatocarcinoma and WA07 pluripotent stem cells with natural biomaterials correlate with in vitro cell behavior.Scientific reports · 2019Article
- Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor.Journal of visualized experiments : JoVE · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic stem cells (ESCs) are pluripotent cells with great therapeutic potentials. The in vitro differentiation of ESC was designed by recapitulating embryogenesis. Significant progress has been made to improve the in vitro differentiation protocols by toning soluble maintenance factors. However, more robust methods for lineage-specific differentiation and maturation are still under development. Considering the complexity of in vivo embryogenesis environment, extracellular matrix (ECM) cues should be considered besides growth factor cues. ECM proteins bind to cells and act as ligands of integrin receptors on cell surfaces. Here, we summarize the role of the ECM and integrins in the formation of three germ layer progenies. Various ECM-integrin interactions were found, facilitating differentiation toward definitive endoderm, hepatocyte-like cells, pancreatic beta cells, early mesodermal progenitors, cardiomyocytes, neuroectoderm lineages, and epidermal cells, such as keratinocytes and melanocytes. In the future, ECM combinations for the optimal ESC differentiation environment will require substantial study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.