ArticleChemical research in toxicology2015
Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect.
Article in Chemical research in toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Functional Variant Discovery Identifies a Novel Genetic Link between SPRY2, Wood Smoke, and Asthma.American journal of respiratory cell and molecular biology · 2026Article
- Asbestos and Iron.International journal of molecular sciences · 2023Review
- Mucus increases cell iron uptake to impact the release of pro-inflammatory mediators after particle exposure.Scientific reports · 2023Article
- Physicochemical and toxicological properties of wood smoke particulate matter as a function of wood species and combustion condition.Journal of hazardous materials · 2023Article
- Integrated genomics approaches identify transcriptional mediators and epigenetic responses to Afghan desert particulate matter in small airway epithelial cells.Physiological genomics · 2022Article
- Deconvolution of multiplexed transcriptional responses to wood smoke particles defines rapid aryl hydrocarbon receptor signaling dynamics.The Journal of biological chemistry · 2021Article
- Ozone Reacts With Carbon Black to Produce a Fulvic Acid-Like Substance and Increase an Inflammatory Effect.Toxicologic pathology · 2020Article
- Oleic acid and derivatives affect human endothelial cell mitochondrial function and vasoactive mediator production.Lipids in health and disease · 2020Article
- Molecular and cellular mechanisms linking air pollution and bone damage.Environmental research · 2020Review
- Air pollutants disrupt iron homeostasis to impact oxidant generation, biological effects, and tissue injury.Free radical biology & medicine · 2020Review
- A Fulvic Acid-like Substance Participates in the Pro-inflammatory Effects of Cigarette Smoke and Wood Smoke Particles.Chemical research in toxicology · 2020Article
- Soluble Wood Smoke Extract Promotes Barrier Dysfunction in Alveolar Epithelial Cells through a MAPK Signaling Pathway.Scientific reports · 2019Article
- Smoking-induced iron dysregulation in the lung.Free radical biology & medicine · 2019Review
- 12-hydroxy oleic acid impairs endothelium-dependent vasorelaxation.Journal of toxicology and environmental health. Part A · 2019Article
- The toxicology of air pollution predicts its epidemiology.Inhalation toxicology · 2018Review
- Human lung injury following exposure to humic substances and humic-like substances.Environmental geochemistry and health · 2018Review
- A critical review of assays for hazardous components of air pollution.Free radical biology & medicine · 2018Review
- The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2017Article
- Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung.Toxicology in vitro : an international journal published in association with BIBRA · 2017Article
- Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis.International journal of chronic obstructive pulmonary diseaseReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The biological effect of an inorganic particle (i.e., silica) can be associated with a disruption in cell iron homeostasis. Organic compounds included in particles originating from combustion processes can also complex sources of host cell iron to disrupt metal homeostasis. We tested the postulate that (1) wood smoke particle (WSP) sequesters host cell iron resulting in a disruption of metal homeostasis, (2) this loss of essential metal results in both an oxidative stress and biological effect in respiratory epithelial cells, and (3) humic-like substances (HULIS), a component of WSP, have a capacity to appropriate cell iron and initiate a biological effect. BEAS-2B cells exposed to WSP resulted in diminished concentrations of mitochondrial (57)Fe, whereas preincubation with ferric ammonium citrate (FAC) prevented significant mitochondrial iron loss after such exposure. Cellular oxidant generation was increased after WSP exposure, but this signal was diminished by coincubation with FAC. Similarly, exposure of BEAS-2B cells to 100 μg/mL WSP activated mitogen-activated protein (MAP) kinases, elevated NF-E2-related factor 2/antioxidant responsive element (Nrf2 ARE) expression, and provoked interleukin (IL)-6 and IL-8 release, but all these changes were diminished by coincubation with FAC. The biological response to WSP was reproduced by exposure to 100 μg/mL humic acid, a polyphenol comparable to HULIS included in the WSP that complexes iron. We conclude that (1) the biological response following exposure to WSP is associated with sequestration of cell iron by the particle, (2) increasing available iron in the cell diminished the biological effects after particle exposure, and (3) HULIS included in WSP can sequester the metal initiating the cell response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.