Evidence map›Paper›PMID 26461171›Full record

Trial reportAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2016

The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.

A DerHovanessian, S S Weigt, V Palchevskiy, M Y Shino, D M Sayah, A L Gregson, P W Noble, S M Palmer, M C Fishbein, B M Kubak and 6 more

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Impact of Allograft Injury Time of Onset on the Development of Chronic Lung Allograft Dysfunction After Lung Transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Trial
  3. Multi-site cytokine levels are predictive of primary graft dysfunction following lung transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Restrictive allograft syndrome vs bronchiolitis obliterans syndrome: Immunological and molecular characterization of circulating exosomes.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. [Predictors for the Bronchiolitis Obliterans Syndrome in Lung Transplant Patient].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020
    Review
  15. Article
  16. Review
  17. Article
  18. Absence of evidence that respiratory viral infections influence pediatric lung transplantation outcomes: Results of the CTOTC-03 study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Observational
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

A DerHovanessianDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, CA.
S S WeigtDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, CA.
V PalchevskiyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, CA.
M Y ShinoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, CA.
D M SayahDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, CA.
A L GregsonDivision of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CA.
P W NobleDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
S M PalmerDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC.
M C FishbeinDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA.
B M KubakDivision of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CA.
A ArdehaliDivision of Cardiothoracic Surgery, Department of Surgery, University of California, Los Angeles, CA.
D J RossDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, CA.
R SaggarDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, CA.
J P LynchDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, CA.
R M ElashoffDepartment of Biomathematics, University of California, Los Angeles, CA.
J A BelperioDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Los Angeles, CA.
University of California, Los Angeles · USCedars-Sinai Medical Center · USDuke University · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Lung Transplant Clinical Trials Network (LT-CTN)U01AI113315 · NIAID · DUKE UNIVERSITY · PI PALMER, SCOTT M · 2014 to 2018
$12.9M
Immune Mechanisms of AlloinjuryR01HL112990 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BELPERIO, JOHN A · 2012 to 2016
$2.2M
Role of T Regulatory Cells in Preventing Human BOSK23HL102220 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREGSON, ARIC L. · 2011 to 2015
$762k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NHLBI NIH HHS K23 HL102220NHLBI NIH HHS R01 HL112990NHLBI NIH HHS R01HL112990NIAID NIH HHS U01 AI113315NIAID NIH HHS U01AI113315
6 · The paper itself

Abstract

Primary graft dysfunction (PGD) is a possible risk factor for bronchiolitis obliterans syndrome (BOS) following lung transplantation; however, the mechanism for any such association is poorly understood. Based on the association of TGF-β with acute and chronic inflammatory disorders, we hypothesized that it might play a role in the continuum between PGD and BOS. Thus, the association between PGD and BOS was assessed in a single-center cohort of lung transplant recipients. Bronchoalveolar lavage fluid concentrations of TGF-β and procollagen collected within 24 h of transplantation were compared across the spectrum of PGD, and incorporated into Cox models of BOS. Immunohistochemistry localized expression of TGF-β and its receptor in early lung biopsies posttransplant. We found an association between PGD and BOS in both bilateral and single lung recipients with a hazard ratio of 3.07 (95% CI 1.76-5.38) for the most severe form of PGD. TGF-β and procollagen concentrations were elevated during PGD (p < 0.01), and associated with increased rates of BOS. Expression of TGF-β and its receptor localized to allograft infiltrating mononuclear and stromal cells, and the airway epithelium. These findings validate the association between PGD and the subsequent development of BOS, and suggest that this association may be mediated by receptor/TGF-β biology.

Indexed as

AgedBiomarkersBronchiolitis ObliteransCase-Control StudiesFemaleFollow-Up StudiesGraft RejectionGraft SurvivalHumansImmunoenzyme TechniquesLung DiseasesLung TransplantationMaleMiddle AgedPostoperative ComplicationsPrimary Graft DysfunctionBiomarkersTransforming Growth Factor beta

Identifiers

PMID26461171
PMCPMC4946573
OpenAlexW1900248703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.