Evidence map›Paper›PMID 26461087›Full record

ArticleCancer cell2015

The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail?

Christopher G Abraham, Joaquín M Espinosa

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cancer cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex.International journal of molecular sciences · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Christopher G AbrahamLinda Crnic Institute for Down Syndrome, University of Colorado Denver School Of Medicine, Aurora, CO 80045, USA; Department of Pharmacology, University of Colorado Denver School Of Medicine, Aurora, CO 80045, USA.
Joaquín M EspinosaLinda Crnic Institute for Down Syndrome, University of Colorado Denver School Of Medicine, Aurora, CO 80045, USA; Department of Pharmacology, University of Colorado Denver School Of Medicine, Aurora, CO 80045, USA. Electronic address: joaquin.espinosa@ucdenver.edu.

Funding

Stress- and Promoter-Specific Mechanisms of Transcritpional Activation by p53R01CA117907 · NCI · UNIVERSITY OF COLORADO DENVER · PI ESPINOSA, JOAQUIN M. · 2006 to 2022
$4.4M
NCI NIH HHS R01 CA117907
6 · The paper itself

Abstract

Mutations in the TP53 gene not only inactivate its tumor suppressor function but also confer this transcription factor with gain-of-function oncogenic properties. A recent paper by Zhu and colleagues reveals a novel molecular pathway driven by mutant p53 and the COMPASS chromatin-modifying complex that is amenable to pharmacological inhibition.

Indexed as

AnimalsChromatinFemaleHumansMaleMutationNeoplasmsTumor Suppressor Protein p53ChromatinTumor Suppressor Protein p53

Identifiers

PMID26461087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.