ArticleInternational journal of radiation oncology, biology, physics2015
Reducing Dose Uncertainty for Spot-Scanning Proton Beam Therapy of Moving Tumors by Optimizing the Spot Delivery Sequence.
Article in International journal of radiation oncology, biology, physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Patient-Specific Deep Reinforcement Learning for Proton Beam Delivery Under Inter-Phase Variations.International journal of particle therapy · 2026Article
- Towards ultra-fast treatments: large energy acceptance beam delivery systems and opportunities for proton beam therapy.Frontiers in oncology · 2026Review
- New energy layer reduction method for rapid intensity-modulated proton therapy (IMPT) using a ridge filter.Medical physics · 2025Article
- Development and experimental validation of an in-house treatment planning system with greedy energy layer optimization for fast IMPT.Medical physics · 2025Article
- Comparison of translation algorithms in determining maximum allowable CTV shifts for Real-Time Gated Proton Therapy (RGPT) robustness evaluation in prostate cancers.Journal of applied clinical medical physics · 2025Article
- Simultaneous reduction of number of spots and energy layers in intensity modulated proton therapy for rapid spot scanning delivery.Medical physics · 2024Article
- AAPM Task Group Report 290: Respiratory motion management for particle therapy.Medical physics · 2022Article
- Roadmap: proton therapy physics and biology.Physics in medicine and biology · 2021Review
- Proton beam radiotherapy for patients with early-stage and advanced lung cancer: a narrative review with contemporary clinical recommendations.Journal of thoracic disease · 2021Review
- Executive Summary of Clinical and Technical Guidelines for Esophageal Cancer Proton Beam Therapy From the Particle Therapy Co-Operative Group Thoracic and Gastrointestinal Subcommittees.Frontiers in oncology · 2021Review
- Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy.Frontiers in oncology · 2021Review
- Pro-con of proton: Dosimetric advantages of intensity-modulation over passive scatter for thoracic malignancies.Technical innovations & patient support in radiation oncology · 2020Article
- Proton therapy for locally advanced non-small cell lung cancer.The British journal of radiology · 2020Review
- Impact of planned dose reporting methods on Gamma pass rates for IROC lung and liver motion phantoms treated with pencil beam scanning protons.Radiation oncology (London, England) · 2019Article
- Article
- Advances in radiotherapy techniques and delivery for non-small cell lung cancer: benefits of intensity-modulated radiation therapy, proton therapy, and stereotactic body radiation therapy.Translational lung cancer research · 2017Review
- Robust optimization in intensity-modulated proton therapy to account for anatomy changes in lung cancer patients.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2015Article
- Advances in proton therapy in lung cancer.Therapeutic advances in respiratory diseaseReview
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Authors and funding
3 authors.
Funding
Abstract
purposeTo develop and validate a novel delivery strategy for reducing the respiratory motion-induced dose uncertainty of spot-scanning proton therapy. METHODS AND MATERIALS: The spot delivery sequence was optimized to reduce dose uncertainty. The effectiveness of the delivery sequence optimization was evaluated using measurements and patient simulation. One hundred ninety-one 2-dimensional measurements using different delivery sequences of a single-layer uniform pattern were obtained with a detector array on a 1-dimensional moving platform. Intensity modulated proton therapy plans were generated for 10 lung cancer patients, and dose uncertainties for different delivery sequences were evaluated by simulation.
resultsWithout delivery sequence optimization, the maximum absolute dose error can be up to 97.2% in a single measurement, whereas the optimized delivery sequence results in a maximum absolute dose error of ≤11.8%. In patient simulation, the optimized delivery sequence reduces the mean of fractional maximum absolute dose error compared with the regular delivery sequence by 3.3% to 10.6% (32.5-68.0% relative reduction) for different patients.
conclusionsOptimizing the delivery sequence can reduce dose uncertainty due to respiratory motion in spot-scanning proton therapy, assuming the 4-dimensional CT is a true representation of the patients' breathing patterns.
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