Evidence map›Paper›PMID 26460945›Full record

ArticleDevelopmental cell2015

Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth.

Davide D'Amico, Laura Antonucci, Laura Di Magno, Sonia Coni, Giulia Sdruscia, Alberto Macone, Evelina Miele, Paola Infante, Lucia Di Marcotullio, Enrico De Smaele and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 83 citations in OpenAlex.

  1. Trial
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  3. Antitumor potential of polyamines in cancer.Acta biochimica et biophysica Sinica · 2025
    Review
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  5. Review
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  7. Polyamine Anabolism Promotes Chemotherapy-Induced Breast Cancer Stem Cell Enrichment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Davide D'AmicoDepartment of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy.
Laura AntonucciDepartment of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, Rome 00161, Italy.
Laura Di MagnoCenter for Life Nanoscience@Sapienza, Italian Institute of Technology, Sapienza University of Rome, Rome 00161, Italy.
Sonia ConiDepartment of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy.
Giulia SdrusciaCenter for Life Nanoscience@Sapienza, Italian Institute of Technology, Sapienza University of Rome, Rome 00161, Italy.
Alberto MaconeDepartment of Biochemical Sciences, Sapienza University of Rome, Rome 00185, Italy.
Evelina MieleCenter for Life Nanoscience@Sapienza, Italian Institute of Technology, Sapienza University of Rome, Rome 00161, Italy.
Paola InfanteCenter for Life Nanoscience@Sapienza, Italian Institute of Technology, Sapienza University of Rome, Rome 00161, Italy.
Lucia Di MarcotullioDepartment of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy; Center for Life Nanoscience@Sapienza, Italian Institute of Technology, Sapienza University of Rome, Rome 00161, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, Rome 00161, Italy.
Enrico De SmaeleDepartment of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy.
Elisabetta FerrettiDepartment of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy.
Laura CiapponiDepartment of Biology and Biotechnologies, Sapienza University of Rome, Rome 00185, Italy.
Felice GiangasperoDepartment of Radiological, Oncological, and Pathological Science, Sapienza University of Rome, Rome 00161, Italy.
John R YatesDepartment of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Enzo AgostinelliDepartment of Biochemical Sciences, Sapienza University of Rome, Rome 00185, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, Rome 00161, Italy.
Beatrice CardinaliCellular Biology and Neurobiology Institute, National Research Council, Monterotondo 00016, Italy.
Isabella ScrepantiDepartment of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, Rome 00161, Italy.
Alberto GulinoDepartment of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy; Center for Life Nanoscience@Sapienza, Italian Institute of Technology, Sapienza University of Rome, Rome 00161, Italy.
Gianluca CanettieriDepartment of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy. Electronic address: gianluca.canettieri@uniroma1.it.
Sapienza University of Rome · ITItalian Institute of Technology · ITCenter for Life Sciences · CNInstitute of Cell Biology and Neurobiology · ITScripps Research Institute · US

Funding

ZDS2P REGULATES SWE1P-DEPENDENT POLARIZED CELL GROWTH IN S CEREVISIAEP41RR011823 · NCRR · UNIVERSITY OF WASHINGTON · PI DAVIS, TRACY · 1996 to 2011
$24.7M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2012 to 2021
$20.7M
NCRR NIH HHS P41 RR011823NIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

Developmental Hedgehog signaling controls proliferation of cerebellar granule cell precursors (GCPs), and its aberrant activation is a leading cause of medulloblastoma. We show here that Hedgehog promotes polyamine biosynthesis in GCPs by engaging a non-canonical axis leading to the translation of ornithine decarboxylase (ODC). This process is governed by AMPK, which phosphorylates threonine 173 of the zinc finger protein CNBP in response to Hedgehog activation. Phosphorylated CNBP increases its association with Sufu, followed by CNBP stabilization, ODC translation, and polyamine biosynthesis. Notably, CNBP, ODC, and polyamines are elevated in Hedgehog-dependent medulloblastoma, and genetic or pharmacological inhibition of this axis efficiently blocks Hedgehog-dependent proliferation of medulloblastoma cells in vitro and in vivo. Together, these data illustrate an auxiliary mechanism of metabolic control by a morphogenic pathway with relevant implications in development and cancer.

Indexed as

Cell ProliferationAMP-Activated Protein KinasesAnimalsApoptosisBlotting, WesternCells, CulturedCerebellar NeoplasmsEmbryo, MammalianFemaleFibroblastsHedgehog ProteinsHEK293 CellsHumansImmunoprecipitationMedulloblastomaMiceAMP-Activated Protein KinasesCNBP protein, humanHedgehog ProteinsOrnithine DecarboxylasePolyaminesRepressor ProteinsRNA-Binding ProteinsRNA, MessengerSUFU protein, human

Identifiers

PMID26460945
PMCPMC4607931
OpenAlexW1855124090

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.