ReviewLancet (London, England)2015
Perforated peptic ulcer.
Review in Lancet (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05767320 (Comparison Between Open vs Laparoscopic Repair of Perforated Peptic Ulcer), which is not on this map. Cited by 144 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison Between Open vs Laparoscopic Repair of Perforated Peptic Ulcer
Who cites it
144 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Perioperative Outcomes of No-Drain Strategy in Primary Repair of Perforated Peptic Ulcer: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Efficacy of laparoscopic barbed sutures in the repair of gastroduodenal perforations: a meta-analysis.BMC gastroenterology · 2026Pooled it
- Perforated peptic ulcers in children: a systematic review.BMC pediatrics · 2025Pooled it
- Unfavorable outcomes and their predictors in patients treated for perforated peptic ulcer disease in Ethiopia: systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Risk factors of perioperative mortality from complicated peptic ulcer disease in Africa: systematic review and meta-analysis.BMJ open gastroenterology · 2020Pooled it
- Perforated and bleeding peptic ulcer: WSES guidelines.World journal of emergency surgery : WJES · 2020Guideline
- Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials.The lancet. Gastroenterology & hepatology · 2018Pooled it
- Randomized, Double-Blind, Active-Controlled, Parallel, Phase 3 Clinical Trial for Evaluating the Efficacy and Safety of Zastaprazan in Patients with Gastric Ulcers.Gut and liver · 2026Trial
- No drains versus drains after perforated peptic ulcer repair: A randomized controlled trail.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Trial
- Functionally significant polymorphisms of the MMP-9 gene are associated with peptic ulcer disease in the Caucasian population of Central Russia.Scientific reports · 2021Trial
- Gastric perforation repaired by hepatic round ligament: Case report and literature review.Medicine · 2026Review
- Interhospital transfer and outcomes after robotic emergency general surgery: a national analysis.Journal of robotic surgery · 2026Article
- A multidimensional approach to frailty in emergency surgery for perforated peptic ulcer.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Evaluation of predictive factors for morbidity and mortality in patients undergoing surgery for peptic ulcer perforation.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Diagnostic utility of a CT upper gastrointestinal protocol for the detection of gastroduodenal leaks.Abdominal radiology (New York) · 2026Article
- Global Burden of Peptic Ulcer Disease (1990-2021) and Projections to 2050: A Comprehensive Analysis of Age, Sex, and Socioeconomic Disparities.Current medical science · 2026Article
- Valentino Syndrome With Histologically Confirmed Acute Appendicitis: A Rare Dual Pathology.Cureus · 2026Article
- Risk Factors for Acute Respiratory Distress Syndrome in Sepsis Caused by Peptic Ulcer Perforation: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
- A-Lines below the Diaphragm - A Case Report of Occult Pneumoperitoneum.Journal of education & teaching in emergency medicine · 2026Article
- Outcomes and Predictors of Mortality in Perforated Versus Non-Perforated Peptic Ulcer Disease: A U.S. Nationwide Propensity-Matched Analysis, 2016-2021.Journal of clinical medicine · 2026Article
84 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Perforated peptic ulcer is a common emergency condition worldwide, with associated mortality rates of up to 30%. A scarcity of high-quality studies about the condition limits the knowledge base for clinical decision making, but a few published randomised trials are available. Although Helicobacter pylori and use of non-steroidal anti-inflammatory drugs are common causes, demographic differences in age, sex, perforation location, and underlying causes exist between countries, and mortality rates also vary. Clinical prediction rules are used, but accuracy varies with study population. Early surgery, either by laparoscopic or open repair, and proper sepsis management are essential for good outcome. Selected patients can be managed non-operatively or with novel endoscopic approaches, but validation of such methods in trials is needed. Quality of care, sepsis care bundles, and postoperative monitoring need further assessment. Adequate trials with low risk of bias are urgently needed to provide better evidence. We summarise the evidence for perforated peptic ulcer management and identify directions for future clinical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.