ArticleAnnals of human genetics2014
Worldwide F(ST) estimates relative to five continental-scale populations.
Article in Annals of human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
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- Ecotypic divergence in Mongolian Scots pine persists via large-effect genetic adaptation and phenotypic plasticity.BMC plant biology · 2025Article
- Recent Statistical Innovations in Human Genetics.Annals of human genetics · 2025Review
- Fast and accurate joint inference of coancestry parameters for populations and/or individuals.PLoS genetics · 2023Article
- Forensic genetics through the lens of Lewontin: population structure, ancestry and race.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Rank-invariant estimation of inbreeding coefficients.Heredity · 2022Article
- A Review of Probabilistic Genotyping Systems:Genes · 2021Review
- Interpretation of DNA data within the context of UK forensic science - evaluation.Emerging topics in life sciences · 2021Article
- Review
- Estimating FST and kinship for arbitrary population structures.PLoS genetics · 2021Article
- Data on likelihood ratios of two-person DNA mixtures interpreted using semi- and fully continuous systems.Data in brief · 2019Article
- Population Stratification in Genetic Association Studies.Current protocols in human genetics · 2017Review
- Population-specific FST values for forensic STR markers: A worldwide survey.Forensic science international. Genetics · 2016Article
- Article
- Genetics, lifestyle and longevity: Lessons from centenarians.Applied & translational genomics · 2015Review
- Choice of population database for forensic DNA profile analysis.Science & justice : journal of the Forensic Science Society · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We estimate the population genetics parameter FST (also referred to as the fixation index) from short tandem repeat (STR) allele frequencies, comparing many worldwide human subpopulations at approximately the national level with continental-scale populations. FST is commonly used to measure population differentiation, and is important in forensic DNA analysis to account for remote shared ancestry between a suspect and an alternative source of the DNA. We estimate FST comparing subpopulations with a hypothetical ancestral population, which is the approach most widely used in population genetics, and also compare a subpopulation with a sampled reference population, which is more appropriate for forensic applications. Both estimation methods are likelihood-based, in which FST is related to the variance of the multinomial-Dirichlet distribution for allele counts. Overall, we find low FST values, with posterior 97.5 percentiles < 3% when comparing a subpopulation with the most appropriate population, and even for inter-population comparisons we find FST < 5%. These are much smaller than single nucleotide polymorphism-based inter-continental FST estimates, and are also about half the magnitude of STR-based estimates from population genetics surveys that focus on distinct ethnic groups rather than a general population. Our findings support the use of FST up to 3% in forensic calculations, which corresponds to some current practice.
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