ReviewNature reviews. Endocrinology2015
Molecular insights into the aetiology of female reproductive ageing.
Review in Nature reviews. Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- The genetic architecture of age at menarche and its causal effects on other traits.Journal of human genetics · 2024Pooled it
- Adverse Childhood Experiences and Early Pubertal Timing Among Girls: A Meta-Analysis.International journal of environmental research and public health · 2019Pooled it
- No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk.Molecular biology and evolution · 2026Article
- Conserved signaling pathways and transcriptional regulators drive ovarian aging across species.Poultry science · 2026Article
- Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs.Nature aging · 2026Article
- Recombinant humanized type III collagen improves ovarian function via ITGA2-mediated mitochondrial function restoration in granulosa cells and extracellular matrix remodeling.Regenerative biomaterials · 2026Article
- Genetic heritability of age at menarche and its association with early menopause in the Korean population: a secondary data analysis.Journal of Korean biological nursing science · 2025Article
- AARS2-catalyzed lactylation induces follicle development and premature ovarian insufficiency.Cell death discovery · 2025Article
- Association of dietary flavonoid intake with reproductive lifespan: a cross-sectional study.European journal of nutrition · 2025Article
- Lipid metabolic reprograming: the unsung hero in breast cancer progression and tumor microenvironment.Molecular cancer · 2025Review
- Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring.Nature aging · 2024Review
- Article
- Understanding the genetic complexity of puberty timing across the allele frequency spectrum.Nature genetics · 2024Article
- Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics.Protein & cell · 2024Article
- Mendelian randomization identifies circulating proteins as biomarkers for age at menarche and age at natural menopause.Communications biology · 2024Article
- The dose-response relationship of pre-menopausal alcohol consumption with age at menopause: a population study of 280 497 women in Norway.International journal of epidemiology · 2023Article
- The Intergeneration Long-Lasting Consequences of Pre-Conceptional Exposure to Sofosbuvir on the Ovarian Tissues of F1 Offspring: Experimental Study on Rats.International journal of molecular sciences · 2023Article
- Single-cell profiling of mouse and primate ovaries identifies high levels ofMolecular therapy. Nucleic acids · 2023Article
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- The prognostic significance of human ovarian aging-related signature in breast cancer after surgery: A multicohort study.Frontiers in immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
As age at pubertal onset declines and age at first pregnancy increases, the mechanisms that regulate female reproductive lifespan become increasingly relevant to population health. The timing of menarche and menopause can have profound effects not only on fertility but also on the risk of diseases such as type 2 diabetes mellitus, cardiovascular disease and breast cancer. Genetic studies have identified dozens of highly penetrant rare mutations associated with reproductive disorders, and also ∼175 common genetic variants associated with the timing of puberty or menopause. These findings, alongside other functional studies, have highlighted a diverse range of mechanisms involved in reproductive ageing, implicating core biological processes such as cell cycle regulation and energy homeostasis. The aim of this article is to review the contribution of such genetic findings to our understanding of the molecular regulation of reproductive timing, as well as the biological basis of the epidemiological links between reproductive ageing and disease risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.