ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2015
Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Time-Resolved Transcriptomic Profiling of Chandipura Virus Infection Reveals Dynamic Host Responses and Host-Directed Therapeutic Targets.International journal of molecular sciences · 2026Article
- Differential short-term and long-term metabolic and cytokine responses to infection of severe fever with thrombocytopenia syndrome virus.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- SARS-CoV-2 S Mutations: A Lesson from the Viral World to Understand How Human Furin Works.International journal of molecular sciences · 2023Article
- Extracellular nucleoprotein exacerbates influenza virus pathogenesis by activating Toll-like receptor 4 and the NLRP3 inflammasome.Cellular & molecular immunology · 2022Article
- A Review and Meta-Analysis of Influenza Interactome Studies.Frontiers in microbiology · 2022Review
- Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report.Molecular and clinical oncology · 2021Article
- Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19.European journal of clinical pharmacology · 2021Review
- Quantifying the effect of trypsin and elastase on in vitro SARS-CoV infections.Virus research · 2021Article
- Does Trypsin Oral Spray (ViruprotectInternational journal of environmental research and public health · 2021Article
- Metabolomic Analysis of Influenza A Virus A/WSN/1933 (H1N1) Infected A549 Cells during First Cycle of Viral Replication.Viruses · 2019Article
- MicroR-9-5p suppresses EV71 replication through targeting NFκB of the RIG-I-mediated innate immune response.FEBS open bio · 2018Article
- Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines.Frontiers in cellular and infection microbiology · 2018Article
- A global perspective on hepatitis B-related single nucleotide polymorphisms and evolution during human migration.Hepatology communications · 2017Article
- IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus-cytokine-trypsin cycle.Archives of virology · 2017Article
- Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome.Frontiers in pediatrics · 2016Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza A virus (IAV) causes significant morbidity and mortality. The knowledge gained within the last decade on the pandemic IAV(H1N1)2009 improved our understanding not only of the viral pathogenicity but also the host cellular factors involved in the pathogenicity of multiorgan failure (MOF), such as cellular trypsin-type hemagglutinin (HA0) processing proteases for viral multiplication, cytokine storm, metabolic disorders and energy crisis. The HA processing proteases in the airway and organs for all IAV known to date have been identified. Recently, a new concept on the pathogenicity of MOF, the "influenza virus-cytokine-trypsin" cycle, has been proposed involving up-regulation of trypsin through pro-inflammatory cytokines, and potentiation of viral multiplication in various organs. Furthermore, the relationship between causative factors has been summarized as the "influenza virus-cytokine-trypsin" cycle interconnected with the "metabolic disorders-cytokine" cycle. These cycles provide new treatment concepts for ATP crisis and MOF. This review discusses IAV pathogenicity on cellular proteases, cytokines, metabolites and therapeutic options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.