ArticleThe Journal of veterinary medical science2016
Efficacy of leflunomide for treatment of refractory inflammatory colorectal polyps in 15 Miniature Dachshunds.
Article in The Journal of veterinary medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Does Neoplastic Disease Negatively Affect Serum Antibody Titers Against Core Vaccines in Dogs?Vaccines · 2026Article
- Retrospective evaluation of leflunomide as second-line immunosuppressive therapy in dogs with meningoencephalomyelitis of unknown origin: 18 cases (2018-2025).Journal of veterinary internal medicine · 2026Article
- Case Report: Fatal presumptive idiosyncratic hepatic necrosis secondary to standard-dose leflunomide administration in a dog.Frontiers in veterinary science · 2025Article
- An inflammatory bowel disease-associated SNP increases local thyroglobulin expression to develop inflammation in miniature dachshunds.Frontiers in veterinary science · 2023Article
- Gene expression of leucine-rich alpha-2 glycoprotein in the polypoid lesion of inflammatory colorectal polyps in miniature dachshunds.The Journal of veterinary medical science · 2020Article
- Comparison of the efficacy of cyclosporine and leflunomide in treating inflammatory colorectal polyps in miniature dachshunds.The Journal of veterinary medical science · 2020Article
- ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs.Journal of veterinary internal medicine · 2019Article
- Analysis of fecal short chain fatty acid concentration in miniature dachshunds with inflammatory colorectal polyps.The Journal of veterinary medical science · 2017Article
- A Retrospective Study on the Safety and Efficacy of Leflunomide in Dogs.Journal of veterinary internal medicine · 2017Article
- Expression of apical junction complex proteins in colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps.The Journal of veterinary medical science · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory colorectal polyp (ICRP), common in miniature dachshunds, presents with hematochezia, tenesmus and mucoid feces. Although an 80% response rate has been reported when treated with prednisolone and cyclosporine, effective treatment is needed for the remaining 20% of ICRP dogs. Leflunomide is an immunosuppressive drug reported as effective in several immune-mediated diseases. In the present study, we retrospectively evaluated the efficacy and adverse effects of leflunomide in 15 ICRP dogs that were refractory to treatment with prednisolone and cyclosporine. Treatment efficacy was assessed by endoscopy, clinical symptoms and rectal palpation. Adverse effects were determined by clinical symptoms and blood testing during follow-up. The leflunomide treatment response rate was 93.3%. The median dosage of leflunomide and the median response time were 3 mg/kg (range: 1.7-4.0 mg/kg) and 35 days (range: 20-119 days), respectively. Adverse effects observed included lethargy (3 dogs), anorexia (1 dog), respiratory symptoms (1 dog), leukocytopenia (2 dogs), thrombocytopenia (1 dog), anemia (1 dog) and liver enzyme elevation (8 dogs). Most of the adverse effects improved with symptomatic treatment and leflunomide discontinuation or dosage reduction. In conclusion, leflunomide treatment is effective in ICRP dogs refractory to treatment with prednisolone and cyclosporine. Because several adverse effects were observed, close monitoring is needed during leflunomide treatment follow-up.
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