ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015
Precision Oncology Framework for Investigation of Exercise As Treatment for Cancer.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data.Cancer research · 2016Pooled it
- Variability in resistance training trajectories of breast cancer patients undergoing therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Trial
- A Feasibility Study Investigating an Exercise Program in Metastatic Cancer Based on the Patient-Preferred Delivery Mode.The oncologist · 2024Trial
- Trial
- Novel Methods for Reporting of Exercise Dose and Adherence: An Exploratory Analysis.Medicine and science in sports and exercise · 2018Trial
- No association between prediagnosis exercise and survival in patients with high-risk primary melanoma: A population-based study.Pigment cell & melanoma research · 2017Trial
- Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial.BMC cancer · 2017Trial
- Exercise therapy in cancer prevention and treatment.Nature reviews. Clinical oncology · 2026Review
- Precision Exercise for Breast Cancer-Related Outcomes: Towards Personalised Training Based on Tumour, Treatment and Patient Characteristics.Sports medicine (Auckland, N.Z.) · 2026Review
- Individualised but Specific Exercise Training Improves Physiologic Reserve and Reduces Frailty in Older Adults with Chronic Lymphocytic Leukaemia: A 12-Week Pragmatic Randomised Controlled Trial.medRxiv : the preprint server for health sciences · 2026Article
- Exercise suppresses breast cancer and reprograms the immune tumor microenvironment, cancer cell intrinsic features, and their interaction.Journal of sport and health science · 2026Article
- A reservation-based clinical trial on inflammatory biomarkers in American Indian/Alaska Native cancer patients: Rationale and design of the Adaptive Prehab Approaches in Cancer Healing and Education (APACHE) Program.Contemporary clinical trials · 2026Article
- Multidisciplinary perspectives in exercise oncology across the translational research continuum.Journal of the National Cancer Institute. Monographs · 2025Review
- Role and mechanisms of exercise therapy in enhancing drug treatment for glioma: a review.Frontiers in immunology · 2025Review
- Pan-Cancer Analysis of Postdiagnosis Exercise and Mortality.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Article
- Article
- Exercise protocols: The gap between preclinical and clinical exercise oncology studies.Metabolism open · 2022Article
- Article
- A novel perspective suggesting high sustained energy expenditure may be net protective against cancer.Evolution, medicine, and public health · 2022Article
- Exercise in People With Cancer: A Spotlight on Energy Regulation and Cachexia.Frontiers in physiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Promising discovery (epidemiologic) data have led to the provocative hypothesis that exercise treatment may improve cancer outcomes, fueling calls for the need for large phase III trials to definitively test this question. Emerging epidemiologic data suggest that the potential efficacy of exercise differs on the basis of tumor subtype. The heterogeneity in response creates the strong hypothesis that a precision oncology approach is required to optimize the benefit and safety of exercise as a candidate antitumor strategy. This commentary has presented one potential translational framework that may facilitate these efforts. It is hoped that the concepts described here will provide the platform for constructive dialogue and interdisciplinary collaboration to optimize the therapeutic promise of exercise treatment.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.