ArticleScientific reports2015
Label-free Quantitative Analysis of Changes in Broiler Liver Proteins under Heat Stress using SWATH-MS Technology.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Omics in heat stress in poultry: implications for immune responses, proteomic changes, and nutritional strategies.Veterinary research communications · 2026Review
- Proteomic insights into broiler stress responses to LED lighting: Effects on liver proteome under neutral, cool, and warm spectra.PloS one · 2025Article
- Label-free liquid chromatography-mass spectrometry comparison of the breast muscle proteome profiles in two fast-growing broilers.Scientific reports · 2024Article
- Label-free liquid chromatography mass spectrometry analysis of changes in broiler liver proteins under transport stress.PloS one · 2024Article
- Appropriate Genetic Approaches for Heat Tolerance and Maintaining Good Productivity in Tropical Poultry Production: A Review.Veterinary sciences · 2023Review
- Chitosan Oligosaccharides Alleviate Heat-Stress-Induced Lipid Metabolism Disorders by Suppressing the Oxidative Stress and Inflammatory Response in the Liver of Broilers.Antioxidants (Basel, Switzerland) · 2023Article
- Anemonefishes: A model system for evolutionary genomics.F1000Research · 2023Review
- Chronic heat stress induces the disorder of gut transport and immune function associated with endoplasmic reticulum stress in growing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Hepatic lipid metabolomics in response to heat stress in local broiler chickens breed (Huaixiang chickens).Veterinary medicine and science · 2021Article
- Pre-exposure toVirulence · 2020Article
- Probing SWATH-MS as a tool for proteome level quantification in a nonmodel fish.Molecular ecology resources · 2020Article
- OsDER1 Is an ER-Associated Protein Degradation Factor That Responds to ER Stress.Plant physiology · 2018Article
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- Effect ofFrontiers in physiology · 2017Article
- Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration.Proteomics. Clinical applications · 2016Article
- Liver transcriptome response to hyperthermic stress in three distinct chicken lines.BMC genomics · 2016Article
- Differential expression analysis of the broiler tracheal proteins responsible for the immune response and muscle contraction induced by high concentration of ammonia using iTRAQ-coupled 2D LC-MS/MS.Science China. Life sciences · 2016Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High temperature is one of the key environmental stressors affecting broiler production efficiency and meat yield. Knowledge of broiler self-regulation mechanisms under heat stress is important for the modern scale of poultry breeding. In the present study, the SWATH strategy was employed to investigate the temporal response of the broiler liver to heat stress. A total of 4,271 proteins were identified and used to generate a reference library for SWATH analysis. During this analysis, 2,377 proteins were quantified, with a coefficient of variation ≤25% among technical and biological replicates. A total of 257 proteins showed differential expression between the control and heat stressed groups. Consistent results for 26 and 5 differential proteins were validated respectively by MRM and western blotting quantitative analyses. Bioinformatics analysis suggests that the up- and down-regulation of these proteins appear involved in the following three categories of cellular pathways and metabolisms: 1) inhibit the ERK signaling pathway; 2) affect broiler liver lipid and amino acid metabolism; 3) induce liver cell immune responses to adapt to the high temperatures and reduce mortality. The study reported here provides an insight into broiler self-regulation mechanisms and shed light on the improved broiler adaptability to high-temperature environments.
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