Evidence map›Paper›PMID 26459883›Full record

ArticleScientific reports2015

Characterization of spatio-temporal epidural event-related potentials for mouse models of psychiatric disorders.

Xin Wang, António Pinto-Duarte, M Margarita Behrens, Xianjin Zhou, Terrence J Sejnowski

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Xin WangHoward Hughes Medical Institute and the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
António Pinto-DuarteHoward Hughes Medical Institute and the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
M Margarita BehrensHoward Hughes Medical Institute and the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Xianjin ZhouDepartment of Psychiatry, University of California at San Diego, La Jolla, CA 92093, USA.
Terrence J SejnowskiHoward Hughes Medical Institute and the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Howard Hughes Medical Institute · USUniversity of California, San Diego · USSalk Institute for Biological Studies · US

Funding

Sp4 Pathway in the Modulation of Sensorimotor Gating and MemoryR01MH073991 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHOU, XIANJIN · 2006 to 2014
$2.9M
Sensitive and Treatable Periods of Brain-Redox Imbalance in SchizophreniaR01MH091407 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI BEHRENS, M MARGARITA, POWELL, SUSAN B · 2010 to 2014
$2.1M
Howard Hughes Medical InstituteNIMH NIH HHS MH073991NIMH NIH HHS MH091407NIMH NIH HHS R01 MH073991NIMH NIH HHS R01 MH091407
6 · The paper itself

Abstract

Distinctive features in sensory event-related potentials (ERPs) are endophenotypic biomarkers of psychiatric disorders, widely studied using electroencephalographic (EEG) methods in humans and model animals. Despite the popularity and unique significance of the mouse as a model species in basic research, existing EEG methods applicable to mice are far less powerful than those available for humans and large animals. We developed a new method for multi-channel epidural ERP characterization in behaving mice with high precision, reliability and convenience and report an application to time-domain ERP feature characterization of the Sp4 hypomorphic mouse model for schizophrenia. Compared to previous methods, our spatio-temporal ERP measurement robustly improved the resolving power of key signatures characteristic of the disease model. The high performance and low cost of this technique makes it suitable for high-throughput behavioral and pharmacological studies.

Indexed as

Evoked PotentialsAnimalsBrain MappingDisease Models, AnimalElectroencephalographyMental DisordersMiceSchizophrenia

Identifiers

PMID26459883
PMCPMC4602219
OpenAlexW2416022450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.