Evidence map›Paper›PMID 26459687›Full record

ArticleSleep medicine2016

Racial/ethnic differences in the associations between obesity measures and severity of sleep-disordered breathing: the Multi-Ethnic Study of Atherosclerosis.

Xiaoli Chen, Rui Wang, Pamela L Lutsey, Phyllis C Zee, Sogol Javaheri, Carmela Alcántara, Chandra L Jackson, Moyses Szklo, Naresh Punjabi, Susan Redline and 1 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Sleep medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Correlation of sleep-disordered breathing with anemia and microcytosis in premenopausal females: the Nagahama study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
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  5. Sleep and periodontal health.Periodontology 2000 · 2024
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  6. Observational
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  14. Publishing in the Journal of Clinical Sleep Medicine: tips from an associate editor.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
  15. Review
  16. A Global Comparison of Anatomic Risk Factors and Their Relationship to Obstructive Sleep Apnea Severity in Clinical Samples.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Xiaoli ChenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: xchen@hsph.harvard.edu.
Rui WangDepartment of Medicine, Harvard Medical School; Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Pamela L LutseyDivision of Epidemiology, Community Health University of Minnesota, Minneapolis, MN 55454, USA.
Phyllis C ZeeDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Sogol JavaheriDepartment of Medicine, Harvard Medical School; Brigham and Women's Hospital, Boston, MA 02115, USA.
Carmela AlcántaraDepartment of Medicine, Center for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY 10032, USA.
Chandra L JacksonDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Harvard Catalyst, Clinical and Translational Science Center, Harvard Medical School, Boston, MA 02115, USA.
Moyses SzkloDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Naresh PunjabiDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.
Susan RedlineDepartment of Medicine, Harvard Medical School; Brigham and Women's Hospital, Boston, MA 02115, USA.
Michelle A WilliamsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Brigham and Women's Hospital · USHarvard University · USColumbia University Irving Medical Center · USJohns Hopkins University · USNorthwestern University · USUniversity of Minnesota · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
Social and Environmental Determinants of Health EquityZIAES103325 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JACKSON, CHANDRA · 2017 to 2025
$12.7M
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPSR01HL098433 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2010 to 2015
$8.2M
Randomized Controlled Study of Adenotonsillectomy for Childhood Sleep ApneaU01HL083075 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI REDLINE, SUSAN S. · 2006 to 2010
$7.6M
Leveraging Family Data to Identify Genetic Variants for Sleep ApneaR01HL113338 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIN, XIHONG, REDLINE, SUSAN S. · 2012 to 2016
$4.4M
Elucidation of the Influence of Sleep Apnea on Risk of Atrial FibrillationR01HL109493 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MEHRA, REENA · 2011 to 2015
$3.7M
Sleep-Disordered Breathing and Risk for CVD and Stroke in the Jackson Heart StudyR01HL110068 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI REDLINE, SUSAN S., WILSON, JAMES GRAHAM · 2012 to 2015
$2.9M
A Planning Study: Sleep Apnea Intervention for Cardiovascular Disease ReductionU34HL105277 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MITTLEMAN, MURRAY A, REDLINE, SUSAN S. · 2010 to 2012
$2.5M
Ecological Link of Psychosocial Stress to Exercise: Personalized PathwaysR01HL115941 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BURG, MATTHEW M, DAVIDSON, KARINA W. · 2012 to 2014
$1.7M
NCATS NIH HHS UL1 TR000170NCATS NIH HHS UL1 TR001102NCI NIH HHS R35 CA197449NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL098433NHLBI NIH HHS R01 HL109493NHLBI NIH HHS R01 HL110068NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL115941NHLBI NIH HHS R21 HL108226NHLBI NIH HHS T32 HL007901NHLBI NIH HHS U01 HL083075NHLBI NIH HHS U34 HL105277NINDS NIH HHS P20 NS076965
6 · The paper itself

Abstract

objectivesThe objective of this study was to evaluate associations between obesity measures and sleep-disordered breathing severity among White, Black, Hispanic, and Chinese Americans.

methodsThe method used in this study was a community-based cross-sectional study of 2053 racially/ethnically diverse adults in the Multi-Ethnic Study of Atherosclerosis. Anthropometry and polysomnography were used to measure obesity and apnea-hypopnea index (AHI). Linear regression models were fitted to investigate associations of body mass index (BMI) and waist circumference with AHI (log transformed) with adjustment for sociodemographics, lifestyle factors, and comorbidities.

resultsThe mean participant age was 68.4 (range: 54-93) years; 53.6% of participants were women. The median AHI was 9.1 events/h. There were significant associations of BMI and waist circumference with AHI in the overall cohort and within each racial/ethnic group. A significant interaction was observed between race/ethnicity and BMI (P

conclusionsAssociations of BMI and waist circumference with AHI were stronger among Chinese than among other racial/ethnic groups. These findings highlight a potential emergence of elevated sleep-disordered breathing prevalence occurring in association with increasing obesity in Asian populations.

Indexed as

AgedAged, 80 and overAnalysis of VarianceAsianAtherosclerosisBlack or African AmericanBody Mass IndexFemaleHispanic or LatinoHumansMaleMiddle AgedObesityPolysomnographyPrevalenceProspective StudiesApnea–hypopnea indexBody mass indexObesityPolysomnographyRace/ethnicitySleep-disordered breathingWaist circumference

Identifiers

PMID26459687
PMCPMC4691213
OpenAlexW1165940587

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.