Evidence map›Paper›PMID 26459626›Full record

ArticleBacteriophage

Experimental evolution and bacterial resistance: (co)evolutionary costs and trade-offs as opportunities in phage therapy research.

Pauline D Scanlan, Angus Buckling, Alex R Hall

Abstract read
In one paragraph

Article in Bacteriophage. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. The Zoetrope effect in phage evolution.Frontiers in microbiology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Bacteriophages in the Control ofAntibiotics (Basel, Switzerland) · 2022
    Review
  11. Application of Bacteriophages on Shiga Toxin-ProducingAntibiotics (Basel, Switzerland) · 2021
    Article
  12. Article
  13. Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Phages for Biofilm Removal.Antibiotics (Basel, Switzerland) · 2020
    Review
  15. Review
  16. Review
  17. Article
  18. Directed Evolution of a Mycobacteriophage.Antibiotics (Basel, Switzerland) · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pauline D ScanlanTeagasc Food Research Center; Moorepark , Fermoy, Co Cork, Ireland.
Angus BucklingBiosciences; ESI; University of Exeter; Penryn Campus , Cornwall, UK.
Alex R HallInstitute of Integrative Biology ; ETH Zürich; Zürich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antagonistic coevolution between bacteria and phages (reciprocal selection for resistance and infectivity) has been demonstrated in a wide range of natural ecosystems, as well as experimental populations of microbes, yet exploiting knowledge of coevolution for the prophylactic and therapeutic use of phages is under-explored. In this addendum to our recent paper we discuss how real-time coevolution studies using experimental populations of bacteria and phages can provide novel insight into the changes in bacterial phenotypes that result from resistance evolution against coevolving phages, and how this may ultimately improve our understanding of phage therapy and ability to design effective treatments.

Indexed as

Antagonistic coevolutionbacterial resistanceexperimental evolutionphage therapypleiotropic costsPseudomonas fluorescenstrade-offs

Identifiers

PMID26459626
PMCPMC4588173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.