ArticleThe Journal of cell biology2015
Surface apposition and multiple cell contacts promote myoblast fusion in Drosophila flight muscles.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Cell fusion after wounding requires plasma membrane damage and endocytosis.bioRxiv : the preprint server for biology · 2026Article
- Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration.Skeletal muscle · 2023Article
- Regulation of the myoblast fusion reaction for muscle development, regeneration, and adaptations.Experimental cell research · 2022Article
- Review
- Development of the indirect flight muscles of Aedes aegypti, a main arbovirus vector.BMC developmental biology · 2021Article
- Heterogeneity and Actin Cytoskeleton in Osteoclast and Macrophage Multinucleation.International journal of molecular sciences · 2020Review
- Review
- Cell Fusion: Merging Membranes and Making Muscle.Trends in cell biology · 2019Review
- Quantitative basis of meiotic chromosome synapsis analyzed by electron tomography.Scientific reports · 2019Article
- The fusogenic synapse at a glance.Journal of cell science · 2019Review
- How cells fuse.The Journal of cell biology · 2019Review
- Electron tomography of mouse LINC complexes at meiotic telomere attachment sites with and without microtubules.Communications biology · 2019Article
- Skeletal muscle regeneration involves macrophage-myoblast bonding.Cell adhesion & migration · 2018Article
- Srf controls satellite cell fusion through the maintenance of actin architecture.The Journal of cell biology · 2018Article
- Myoblast fusion confusion: the resolution begins.Skeletal muscle · 2018Review
- Acting on identity: Myoblast fusion and the formation of the syncytial muscle fiber.Seminars in cell & developmental biology · 2017Review
- Article
- Live Imaging of Myogenesis in Indirect Flight Muscles inBio-protocol · 2017Article
- Metamorphosis of the Drosophila visceral musculature and its role in intestinal morphogenesis and stem cell formation.Developmental biology · 2016Article
- Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion.Journal of cell science · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusion of individual myoblasts to form multinucleated myofibers constitutes a widely conserved program for growth of the somatic musculature. We have used electron microscopy methods to study this key form of cell-cell fusion during development of the indirect flight muscles (IFMs) of Drosophila melanogaster. We find that IFM myoblast-myotube fusion proceeds in a stepwise fashion and is governed by apparent cross talk between transmembrane and cytoskeletal elements. Our analysis suggests that cell adhesion is necessary for bringing myoblasts to within a minimal distance from the myotubes. The branched actin polymerization machinery acts subsequently to promote tight apposition between the surfaces of the two cell types and formation of multiple sites of cell-cell contact, giving rise to nascent fusion pores whose expansion establishes full cytoplasmic continuity. Given the conserved features of IFM myogenesis, this sequence of cell interactions and membrane events and the mechanistic significance of cell adhesion elements and the actin-based cytoskeleton are likely to represent general principles of the myoblast fusion process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.