Evidence map›Paper›PMID 26459449›Full record

ReviewCellular and molecular life sciences : CMLS2016

Innate lymphoid cells in intestinal immunity and inflammation.

John W Bostick, Liang Zhou

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Guardians within: Cross-talk between the gut microbiome and host immune system.World journal of gastrointestinal pathophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John W BostickDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Liang ZhouDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. l-zhou@northwestern.edu.

Funding

AhR activation in Th17 and Treg cell differentiationR01AI089954 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZHOU, LIANG · 2010 to 2014
$1.9M
NIAID NIH HHS AI089954NIAID NIH HHS R01 AI089954
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a new and distinct family of innate immune cells that play an important role in immunity and inflammation. In this review, we focus on the role of ILCs in mucosal tissues, especially in the gut, in health and disease. ILCs support intestinal homeostasis by protecting the intestine from pathogens, contributing to the development of gut lymphoid tissue, and helping to repair injuries. By cooperating with epithelial cells and other innate and adaptive immune cells, ILCs participate in the control of pathogens and tolerance of commensal bacteria. The development and maintenance of ILCs are influenced by nutrients and metabolites sourced from diet and/or gut bacteria. ILCs have been shown to be involved in host metabolism and to participate in various diseases of the intestine including infectious and chronic inflammatory diseases, and cancer. Thus, the elucidation of ILC biology provides an exciting potential for development of novel therapeutic means to modulate immune responses in various disease settings.

Indexed as

Immunity, InnateAnimalsBacteriaDietGastrointestinal MicrobiomeHomeostasisHumansInflammationIntestinal MucosaIntestinesLymphocytesCommensalsDietHomeostasisMetabolismNutrition

Identifiers

PMID26459449
PMCPMC11108440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.